SIVA1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.[1][2]

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.[2]

Interactions

SIVA1 has been shown to interact with CD27.[1]

Siva (protein)

Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. [3]

See also

References

  1. 1.0 1.1 Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jul 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc Natl Acad Sci U S A. 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. PMC 21052. PMID 9177220.
  2. 2.0 2.1 "Entrez Gene: SIVA1 SIVA1, apoptosis-inducing factor".
  3. Fortin A, MacLaurin JG, Arbour N, et al. (July 2004). "The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1". J. Biol. Chem. 279 (27): 28706–14. doi:10.1074/jbc.M400376200. PMID 15105421.

Further reading