Raynaud's phenomenon causes

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Raynaud's phenomenon Microchapters


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Differentiating Raynaud's phenomenon from other Diseases

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Editors-In-Chief: Asghar Fakhri, M.D., Duane S. Pinto, M.D. and C. Michael Gibson, M.S., M.D.



Causes by Organ System

Cardiovascular Arteriosclerosis obliterans, Arteriovenous fistula, Atherosclerosis, Embolism, Peripheral emboli, Peripheral vascular disease, Subclavian aneurysms, Atrial myxoma, Polyarteritis nodosa, Takayasu arteritis, Temporal arteritis, Thromboangitis obliterans, Wegener's granulomatosis
Chemical / poisoning Arsenicals, Lead, Polyvinyl chloride, Thallium, Vinyl chloride
Dermatologic No underlying causes
Drug Side Effect Amphetamines, Arsenic trioxide, Atenolol, Beta-blockers, Bleomycin, Bromocriptine, Cabergoline, Clonidine, Cyclosporin, Cytotoxic drugs, Ergometrine, Ergotamine, Hormonal contraceptives, Imipramine, Lysuride, Melarsoprol, Methylphenidate, Methysergide, Pergolide, Piribedil, Pramipexole, Propranolol, Pseudoephedrine, Ropinirole, Sulfasalazine , Vinblastine
Ear Nose Throat No underlying causes
Endocrine Acromegaly, Hypothyroidism, Growth hormone secreting pituitary adenoma
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Fabry disease
Hematologic Cold agglutinins, Cryoglobulinemia, Mixed essential cryoglobulinaemia, Leukemia, Myeloma, Polycythaemia rubra vera, Waldenstrom macroglobulinaemia, Paroxysmal cold haemoglobinuria
Iatrogenic No underlying causes
Infectious Disease Hepatitis B antigenemia, Mycoplasma pneumoniae, Poliomyelitis
Musculoskeletal / Ortho Carpal tunnel syndrome, Cervical rib, Scalenus-anticus syndrome, Scoliosis, Thoracic outlet syndrome,Dermatomyositis, Polymyositis, Rheumatoid arthritis
Neurologic Intervertebral disc herniation, Peripheral neuropathy, Poliomyelitis, Reflex sympathetic dystrophy, Syringomyelia, Transverse myelitis, Spinal tumor, Multiple sclerosis
Nutritional / Metabolic Fabry disease
Obstetric/Gynecologic No underlying causes
Oncologic Atrial myxoma, Growth hormone secreting pituitary adenoma, Leukemia, Malignancy leading to paraneoplatic raynaud phenomenon, Myeloma, Phaeochromocytoma, Polycythaemia rubra vera, Spinal tumor, Waldenstrom macroglobulinaemia
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric Anorexia nervosa
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Amyloidosis, Antisynthetase syndrome, Calcinosis-Raynaud-sclerodactyly-telangiectasia syndrome, Dermatomyositis, Mixed connective tissue disease, Multiple sclerosis, Paroxysmal cold haemoglobinuria, Polyarteritis nodosa, Polymyositis, Rheumatoid Arthritis, Rheumatoid disease, Scleroderma, Sicca syndrome, Sjogen's Syndrome, Systemic lupus erythematosus, Systemic sclerosis, Takayasu arteritis, Temporal arteritis, Thromboangitis obliterans, Wegener's granulomatosis
Sexual No underlying causes
Trauma Hand arm vibration syndrome, Hypothenar Hammer Syndrome
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Erythromelalgia, Exposure to the cold, Frost bite, Raynaud disease, Smoking, Amyloidosis

Causes in Alphabetical Order

It is important to realise that Raynaud's can herald these diseases by periods of more than 20 years in some cases, making it effectively their first presenting symptom. This can be the case in the CREST syndrome, of which Raynaud's is a part.


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