Rapidly progressive glomerulonephritis history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

Overview

In rapidly progressive glomerulonephritis The most common early presentation is flulike symptoms characterized by malaise, fever, arthralgias, myalgias, anorexia, and weight loss. This is seen in more than 90% of patients. Following the prodrome, the other symptoms include abdominal pain, painful cutaneous nodules or ulcerations, and a migratory polyarthropathy. When pulmonary or upper airway involvement is present, patients complain of sinusitis symptoms, cough, and hemoptysis.

History

Patients with rapidly progressive glomerulonephritis may have a positive history of

• Anuria
• Oliguria
• Macroscopic hematuria
• Edema

Symptoms

Common Symptoms

Common symptoms of [disease] include:

• Malaise
• Fever
• Arthralgias
• Myalgias
• Anorexia
• Weight loss

• Macroscopic hematuria
• Edema
• Oliguria
• Cough

Less Common Symptoms

• Abdominal pain
• Painful cutaneous nodules or ulcerations
• Migratory polyarthropathy.

• Severe hematuria
• Dyspnea

When the cause of RPGN is Goodpasture syndrome or vasculitis that involves the lungs (such as Wegener granulomatosis), patients may present with:

• Cough
• Hemoptysis
• Dyspnea
• Nasal bleeding, obstruction, or sinusitis.