Rapidly progressive glomerulonephritis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2]

Overview

Rapidly progressive glomerulonephritis can be caused by multiple factors.These include life threatening conditions such as sepsis and other pre existing renal diseases.Infections, drugs and some types of cancer also cause RPGN.

Causes

Life-threatening Causes

Common Causes

Common causes of rapidly progressive glomerulonephritis may include[1][2][3]

  • Renal-limited necrotizing crescentic glomerulonephritis (NCGN)
  • Eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome

Less Common Causes

Less common causes of rapidly progressive glomerulonephritis include:

Genetic Causes

  • Rapidly progressive glomerulonephritis is more common in people who have HLA DP1, DQ and DRB4s.

Causes by Organ System

Cardiovascular Infective endocarditis
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Hydralazine,Allopurinol,Rifampin
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic Colon cancer
Genetic HLA DP1, HLA DQ, HLA DRB4s
Hematologic Lymphoma, Henoch-Schönlein purpural)
Iatrogenic No underlying causes
Infectious Disease Hepatitis B,Hepatitis C
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Colon cancer, Pulmonary cancer, Lymphoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Lung cancer
Renal/Electrolyte Postinfectious glomerulonephritis,Lupus nephritis,Immunoglobulin A nephropathy ,Membranoproliferative glomerulonephritis, Renal-limited necrotizing crescentic glomerulonephritis (NCGN)
Rheumatology/Immunology/Allergy Goodpasture syndrome, SLE, Behcet's disease, Granulomatosis with polyangiitis (Wegener granulomatosis), Microscopic polyangiitis, Eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome),
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Sepsis

Causes in Alphabetical Order

List the causes of the disease in alphabetical order:

References

  1. Huang XR, Tipping PG, Apostolopoulos J, Oettinger C, D'Souza M, Milton G; et al. (1997). "Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats". Clin Exp Immunol. 109 (1): 134–42. PMC 1904710. PMID 9218836.
  2. Syed R, Rehman A, Valecha G, El-Sayegh S (2015). "Pauci-Immune Crescentic Glomerulonephritis: An ANCA-Associated Vasculitis". Biomed Res Int. 2015: 402826. doi:10.1155/2015/402826. PMC 4673333. PMID 26688808.
  3. Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K; et al. (2010). "Histopathologic classification of ANCA-associated glomerulonephritis". J Am Soc Nephrol. 21 (10): 1628–36. doi:10.1681/ASN.2010050477. PMID 20616173.
  4. Couser WG (1988). "Rapidly progressive glomerulonephritis: classification, pathogenetic mechanisms, and therapy". Am J Kidney Dis. 11 (6): 449–64. PMID 3287904.
  5. Roy S, Murphy WM, Arant BS (1981). "Poststreptococcal crescenteric glomerulonephritis in children: comparison of quintuple therapy versus supportive care". J Pediatr. 98 (3): 403–10. PMID 7205449.
  6. Yang G, Tang Z, Chen Y, Zeng C, Chen H, Liu Z; et al. (2005). "Antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with anti-GBM crescentic glomerulonephritis". Clin Nephrol. 63 (6): 423–8. PMID 15960143.
  7. Heeringa P, Brouwer E, Klok PA, Huitema MG, van den Born J, Weening JJ; et al. (1996). "Autoantibodies to myeloperoxidase aggravate mild anti-glomerular-basement-membrane-mediated glomerular injury in the rat". Am J Pathol. 149 (5): 1695–706. PMC 1865281. PMID 8909258.

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