Pseudo Cushing's syndrome differential diagnosis
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Differentiating Pseudo Cushing's syndrome from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]}; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Pseudo-Cushing's syndrome must be differentiated from other diseases that cause hypertension, obesity, and hyperandrogenism, such as Metabolic syndrome X and Cushing's syndrome. Depression may also cause similar symptoms.
Differentiating Pseudo Cushing's Syndrome from other Diseases
- Differentiation from Cushing's is extremely difficult
- Causes of Cushing's should be excluded with imaging of the lungs, adrenal glands, and pituitary gland - but these often appear normal in Cushing's anyway
- In the alcoholic patient with pseudo-Cushing's, admission to hospital (and avoidance of alcohol) will result in normal midnight cortisol levels within 5 days, excluding Cushing's[1]
- Diseases with similar symptoms
The table below summarizes the findings that differentiate pseudo-Cushing's disease from other conditions that may cause hypertension, hyperandrogenism, and obesity. Facial plethora, skin changes, osteoporosis, nephrolithiasis and neuropsychiatric conditions.[2][3][4][5]
References
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