Proguanil

Proguanil

File:Proguanil.svg
Clinical data
ATC code	P01BB01 (WHO)
Pharmacokinetic data
Elimination half-life	~20 h
Identifiers
IUPAC name 1-(4-chlorophenyl)-2-(N'-propan-2-ylcarbamimidoyl) guanidine
CAS Number	500-92-5
PubChem CID	4923
DrugBank	APRD00188
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C11H16ClN5
Molar mass	253.731 g/mol

Proguanil (proguanil hydrochloride) is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.

Proguanil is effective against sporozoites.

Proguanil is usually taken in combination with another anti-malarial drug such as atovaquone (e.g., in the drug Malarone) or chloroquine. Malarone has fewer side effects than mefloquine, but can be more expensive because it's taken daily. Proguanil is taken with Atovaquone for chloroquine-resistant and multidrug resistant strains of P. falciparum and P. vivax.

Proguanil also known as Paludrine (Astra Zeneca)

References

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