Proamanullin

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Proamanullin
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Names
Other names
2-L-Proline-3-isoleucine-alpha-amanitin
Identifiers
3D model (JSmol)
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Properties
C39H54N10O11S
Molar mass 870.97 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms.

Toxicology

Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]

References

  1. Cochet-Meilhac M, Chambon P (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. PMID 4601749. Unknown parameter |month= ignored (help)

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