Pristinamycin

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Pristinamycin
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pristinamycin (INN), also spelled pristinamycine, is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections. It is a streptogramin group antibiotic, similar to virginiamycin, derived from the bacterium Streptomyces pristina spiralis. It is marketed in Europe by Sanofi-Aventis under the trade name Pyostacine.

Pristinamycin is a mixture of two components that have a synergistic antibacterial action. Pristinamycin I is a macrolide, and results in pristinamycin having a similar spectrum of action to erythromycin. Pristinamycin II is a depsipeptide.[1]

Clinical use

Despite the macrolide component, it is effective against erythromycin-resistant staphylococci and strepcococci.[2][3] Importantly, it is active against methicillin-resistant Staphylococcus aureus (MRSA). Its usefulness for severe infections, however, may be limited by the lack of an intravenous formulation owing to its poor solubility.[4] Nevertheless it is sometimes used as an alternative to rifampicin+fusidic acid or linezolid for the treatment of MRSA.

The lack of an intravenous formulation led to the development of the pristinamycin-derivative quinupristin/dalfopristin, which may be administered intravenously for more severe MRSA infections.

See also

Footnotes

  1. Hamilton-Miller J (1991). "From foreign pharmacopoeias: 'new' antibiotics from old?". J Antimicrob Chemother. 27 (6): 702–5. PMID 1938680.
  2. Weber P (2001). "[Streptococcus pneumoniae: lack of emergence of pristinamycin resistance]". Pathol Biol (Paris). 49 (10): 840–5. PMID 11776696.
  3. Leclercq R, Soussy C, Weber P, Moniot-Ville N, Dib C (2003). "[In vitro activity of the pristinamycin against the isolated staphylococci in the french hospitals in 1999-2000]". Pathol Biol (Paris). 51 (7): 400–4. PMID 12948760.
  4. Edited by Sean C. Sweetman, ed. (November 30, 2004). Martindale: The complete drug reference (34th edition ed.). London: Pharmaceutical Press. ISBN 0-85369-550-4.

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| group5 = Clinical Trials Involving Pristinamycin | list5 = Ongoing Trials on Pristinamycin at Clinical Trials.govTrial results on PristinamycinClinical Trials on Pristinamycin at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Pristinamycin | list6 = US National Guidelines Clearinghouse on PristinamycinNICE Guidance on PristinamycinNHS PRODIGY GuidanceFDA on PristinamycinCDC on Pristinamycin


| group7 = Textbook Information on Pristinamycin | list7 = Books and Textbook Information on Pristinamycin


| group8 = Pharmacology Resources on Pristinamycin | list8 = AND (Dose)}} Dosing of PristinamycinAND (drug interactions)}} Drug interactions with PristinamycinAND (side effects)}} Side effects of PristinamycinAND (Allergy)}} Allergic reactions to PristinamycinAND (overdose)}} Overdose information on PristinamycinAND (carcinogenicity)}} Carcinogenicity information on PristinamycinAND (pregnancy)}} Pristinamycin in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Pristinamycin


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Pristinamycin | list9 = AND (pharmacogenomics)}} Genetics of PristinamycinAND (pharmacogenomics)}} Pharmacogenomics of PristinamycinAND (proteomics)}} Proteomics of Pristinamycin


| group10 = Newstories on Pristinamycin | list10 = Pristinamycin in the newsBe alerted to news on PristinamycinNews trends on Pristinamycin


| group11 = Commentary on Pristinamycin | list11 = Blogs on Pristinamycin

| group12 = Patient Resources on Pristinamycin | list12 = Patient resources on PristinamycinDiscussion groups on PristinamycinPatient Handouts on PristinamycinDirections to Hospitals Treating PristinamycinRisk calculators and risk factors for Pristinamycin


| group13 = Healthcare Provider Resources on Pristinamycin | list13 = Symptoms of PristinamycinCauses & Risk Factors for PristinamycinDiagnostic studies for PristinamycinTreatment of Pristinamycin

| group14 = Continuing Medical Education (CME) Programs on Pristinamycin | list14 = CME Programs on Pristinamycin

| group15 = International Resources on Pristinamycin | list15 = Pristinamycin en EspanolPristinamycin en Francais

| group16 = Business Resources on Pristinamycin | list16 = Pristinamycin in the MarketplacePatents on Pristinamycin

| group17 = Informatics Resources on Pristinamycin | list17 = List of terms related to Pristinamycin


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