Polycythemia interventions
Jump to navigation
Jump to search
|
Polycythemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Polycythemia interventions On the Web |
|
American Roentgen Ray Society Images of Polycythemia interventions |
|
Risk calculators and risk factors for Polycythemia interventions |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]Zaida Obeidat, M.D.
Indications
- Phlebotomy is the backbone of therapy, treatment with phlebotomy alone associated with a longer median survival compared to the use of chlorambucil or radioactive phosphorous based on a trial conducted by PV study group. Repeated phlebotomies help in cytoreduction and reduce hyperviscosity in addition to induce a state of iron deficiency which can help retard red cell proliferation. Weekly sessions are conducted, by remove 500ml of blood until a target hematocrit of under 45% is obtained. This can lower rates of cardiovascular deaths and major thrombotic episodes in patients kept under this threshold based on a trial conducted in Italy.
- For secondary polycythemia, phlebotomy is usually reserved for the following conditions:
- Chronic lung diseases
- Cyanotic heart diseases
- Post renal transplant patients with hypertension and erythrocytosis, not responding to optimal doses of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARB) [1] [2]