Paroxysmal nocturnal hemoglobinuria physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [3]

Overview

Patients with paroxysmal nocturnal hemoglobinuria usually appear tired. Physical examination of patients with PNH is usually remarkable for fever, skin pallor, skin ecchymoses and skin nodules. Physical examination may show abdominal distension if PNH is associated with Budd-Chiari syndrome.

Physical Examination

Appearance of the Patient

• Patients with paroxysmal nocturnal hemoglobinuria usually appear tired

Vital Signs

• Fever may be present due to infections

Skin

• Pallor
• Skin ecchymoses
• Skin nodules if it is associated with dermal vein thrombosis

HEENT

• Mucosal pallor

Neck

• Neck examination of patients with paroxysmal nocturnal hemoglobinuria is usually normal

Lungs

• Pulmonary examination of patients with paroxysmal nocturnal hemoglobinuria is usually normal

Heart

• Cardiovascular examination of patients with paroxysmal nocturnal hemoglobinuria is usually normal

Abdomen

• Abdominal distention if associated with Budd-Chiari syndrome
• Hepatomegaly
• Splenomegaly

Genitourinary

• Genitourinary examination of patients with paroxysmal nocturnal hemoglobinuria is usually normal