Papular purpuric gloves and socks syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Synonyms and keywords: PPGSS

Overview

Papular purpuric gloves and socks syndrome (PPGSS) is an uncommon cutaneous condition with a typical purpuric exanthem limited to hands and feet.

Causes

An association with parvovirus B19 has been described.^[1]
The syndrome has also been associated with several viruses such as HHV6, measles and coxsackie B6

Epidemiology and Demographics

PPGSS occurs primarily in teenagers and young adults.

Natural History, Complications and Prognosis

Rash and fever completely resolved in less than 3 days.
The disease has a short course and a benign prognosis.

Diagnosis

Symptoms

PPGSS is characterized by

Physical Examination

Extremities

Edema
Erythema of the hands and feet, ^[2]

Laboratory Findings

All laboratory tests are normal.
Positive serology for Parvovirus B19. IgM is positive but not IgG.^[3]
Viral DNA test to detect the virus.

References

↑ Fölster-Holst R, Kreth HW (2009). "Viral exanthems in childhood--infectious (direct) exanthems. Part 2: Other viral exanthems". J Dtsch Dermatol Ges. 7 (5): 414–9. doi:[//doi.org/10.1111%2Fj.1610-%0A%0A0387.2008.06869.x 10.1111/j.1610- 0387.2008.06869.x] Check |doi= value (help). PMID 18808380. Unknown parameter |month= ignored (help); line feed character in |author= at position 15 (help); line feed character in |journal= at position 3 (help); line feed character in |doi= at position 16 (help)
↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. line feed character in |author= at position 43 (help)
↑ Parez N, Dehée A, Michel Y, Veinberg F, Garbarg-Chenon A (2009). "Papular-purpuric gloves and socks syndrome associated with B19V infection in a 6-year-old child". J. Clin. Virol. 44 (2): 167–9. doi:10.1016/j.jcv.2008.11.013. PMID 19129008. Unknown parameter |month= ignored (help); line feed character in |title= at position 44 (help)

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[pmid18808380-1] Fölster-Holst R, Kreth HW (2009). "Viral exanthems in childhood--infectious (direct) exanthems. Part 2: Other viral exanthems". J Dtsch Dermatol Ges. 7 (5): 414–9. doi:[//doi.org/10.1111%2Fj.1610-%0A%0A0387.2008.06869.x 10.1111/j.1610- 0387.2008.06869.x] Check |doi= value (help). PMID 18808380. Unknown parameter |month= ignored (help); line feed character in |author= at position 15 (help); line feed character in |journal= at position 3 (help); line feed character in |doi= at position 16 (help)

[Andrews-2] James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. line feed character in |author= at position 43 (help)

[pmid19129008-3] Parez N, Dehée A, Michel Y, Veinberg F, Garbarg-Chenon A (2009). "Papular-purpuric gloves and socks syndrome associated with B19V infection in a 6-year-old child". J. Clin. Virol. 44 (2): 167–9. doi:10.1016/j.jcv.2008.11.013. PMID 19129008. Unknown parameter |month= ignored (help); line feed character in |title= at position 44 (help)

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