Phospholipase D family, member 5 is a protein that in humans is encoded by the PLD5 gene .[1]
Model organisms Model organisms have been used in the study of PLD5 function. A conditional knockout mouse line, called Pld5tm1a(KOMP)Wtsi [6] [7] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute .[8] [9] [10]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4] [11] mutant mice but no significant abnormalities were observed.[4]
References
↑ "Entrez Gene: PLD5 phospholipase D family, member 5" . Retrieved 2011-12-04 .↑ "Salmonella infection data for Pld5" . Wellcome Trust Sanger Institute.↑ "Citrobacter infection data for Pld5" . Wellcome Trust Sanger Institute.↑ 4.0 4.1 4.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 (S248). doi :10.1111/j.1755-3768.2010.4142.x . ↑ Mouse Resources Portal , Wellcome Trust Sanger Institute.↑ "International Knockout Mouse Consortium" .↑ "Mouse Genome Informatics" .↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature . 474 (7351): 262–3. doi :10.1038/474262a . PMID 21677718 . ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 .
Further reading
Anney, R.; Klei, L.; Pinto, D.; Regan, R.; Conroy, J.; Magalhaes, T. R.; Correia, C.; Abrahams, B. S.; Sykes, N.; Pagnamenta, A. T.; Almeida, J.; Bacchelli, E.; Bailey, A. J.; Baird, G.; Battaglia, A.; Berney, T.; Bolshakova, N.; Bölte, S.; Bolton, P. F.; Bourgeron, T.; Brennan, S.; Brian, J.; Carson, A. R.; Casallo, G.; Casey, J.; Chu, S. H.; Cochrane, L.; Corsello, C.; Crawford, E. L.; Crossett, A. (2010). "A genome-wide scan for common alleles affecting risk for autism" . Human Molecular Genetics . 19 (20): 4072–4082. doi :10.1093/hmg/ddq307 . PMC 2947401 PMID 20663923 . Rose, J.; Behm, F.; Drgon, T.; Johnson, C.; Uhl, G. R. (2010). "Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score" . Molecular Medicine . 16 (7–8): 247–253. doi :10.2119/molmed.2009.00159 . PMC 2896464 PMID 20379614 . McCauley, J. L.; Zuvich, R. L.; Bradford, Y.; Kenealy, S. J.; Schnetz-Boutaud, N.; Gregory, S. G.; Hauser, S. L.; Oksenberg, J. R.; Mortlock, D. P.; Pericak-Vance, M. A.; Haines, J. L. (2009). "Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis" . Genes and Immunity . 10 (7): 624–630. doi :10.1038/gene.2009.53 . PMC 2765552 PMID 19626040 .
