Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2gene.[1][2][3] It is one of several PAF acetylhydrolases.
Function
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.[3]
References
↑Hattori K, Adachi H, Matsuzawa A, Yamamoto K, Tsujimoto M, Aoki J, Hattori M, Arai H, Inoue K (Dec 1996). "cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase". The Journal of Biological Chemistry. 271 (51): 33032–8. doi:10.1074/jbc.271.51.33032. PMID8955149.
Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM (Jul 1997). "Platelet-activating factor acetylhydrolases". The Journal of Biological Chemistry. 272 (29): 17895–8. doi:10.1074/jbc.272.29.17895. PMID9218411.
Umemura K, Kato I, Hirashima Y, Ishii Y, Inoue T, Aoki J, Kono N, Oya T, Hayashi N, Hamada H, Endo S, Oda M, Arai H, Kinouchi H, Hiraga K (Mar 2007). "Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia". Stroke: A Journal of Cerebral Circulation. 38 (3): 1063–8. doi:10.1161/01.STR.0000257981.09329.d2. PMID17272759.
Schmidt EB, Koenig W, Khuseyinova N, Christensen JH (Jan 2008). "Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids". Atherosclerosis. 196 (1): 420–4. doi:10.1016/j.atherosclerosis.2006.11.027. PMID17157859.
Unno N, Sakaguchi T, Nakamura T, Yamamoto N, Sugatani J, Miwa M, Konno H (Jul 2006). "A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease". The Journal of Surgical Research. 134 (1): 36–43. doi:10.1016/j.jss.2006.02.058. PMID16650870.
Marques M, Pei Y, Southall MD, Johnston JM, Arai H, Aoki J, Inoue T, Seltmann H, Zouboulis CC, Travers JB (Oct 2002). "Identification of platelet-activating factor acetylhydrolase II in human skin". The Journal of Investigative Dermatology. 119 (4): 913–9. doi:10.1046/j.1523-1747.2002.01859.x. PMID12406338.
Min JH, Wilder C, Aoki J, Arai H, Inoue K, Paul L, Gelb MH (Apr 2001). "Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme". Biochemistry. 40 (15): 4539–49. doi:10.1021/bi002600g. PMID11294621.
