Nucleoporin 205

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.[1][2][3]

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.[1] It has also been recently shown that Nup205 is required for proper viral gene expression.[4]

References

  1. 1.0 1.1 "Entrez Gene: NUP205 nucleoporin 205kDa".
  2. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  3. Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (October 1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
  4. Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG. Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression. J Virol. 2014 Nov;88(22):13249-59. doi: 10.1128/JVI.00933-14. Epub 2014 Sep 10. PMID 25210169; PMC 4249058.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.