Motavizumab

Motavizumab

Monoclonal antibody
Type	Whole antibody
Source	Template:Infobox drug/mab source
Target	RSV glycoprotein F
Clinical data
Trade names	Numax
Routes of administration	i.v.
ATC code	J06BB17 (WHO)
Pharmacokinetic data
Protein binding	None
Identifiers
CAS Number	677010-34-3 N
ChemSpider	NA Y
UNII	50Y163LK8Q
KEGG	D06621 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C6476H10014N1706O2008S48
Molar mass	Approximately 148 kDa
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Clinical Trials
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Motavizumab (proposed INN, trade name Numax) is a humanized monoclonal antibody. It is being investigated by MedImmune (today a subsidiary of AstraZeneca) for the prevention of respiratory syncytial virus infection in high-risk infants. As of September 2009, it is undergoing Phase II and III clinical trials.

In June 2010, the FDA Antiviral Drugs Advisory Committee declined to endorse MedImmune's request for licensure of Motavizumab in a 14 to 3 decision. The members of that panel cited several reasons for the decision, and many were concerned that "we're not looking at a product that has evidence of superiority in terms of efficacy" when compared to the already available monoclonal antibody Palivizumab.

In December 2010, AstraZeneca in a stock market statement stated that it would be writing down $445m (£286m) after discontinuing a key development programme for Motavizumab. The company stated that it would no longer develop Motavizumab for the prevention of respiratory syncytial virus (RSV), and as a result was withdrawing its licence application to the US Food and Drug Administration. It added that it would continue to develop Motavizumab for other treatments of RSV.