Meglumine antimoniate

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Meglumine Antimoniate
GLUCANTIM® WHO Prescribing Information
Description
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and Keywords: Meglumine antimonate

Overview

Meglumine antimoniate is a medicine used for treating leishmaniasis. It is manufactured by Aventis and sold as Glucantime in France, and Glucantim in Italy.

It belongs to a group of compounds known as the pentavalent antimonials. It is administered by intramuscular injection.

Category

Antiparasitic

Brand Names

GLUCANTIM®, GLUCANTIME® (NOT AVAILABLE)

WHO Model Prescribing Information

Description | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | How Supplied

Mechanism of Action

The mechanism of action of meglumine antimoniate is unknown, but may involve inhibition of the parasite's glycolytic and fatty acid oxidative activity resulting in decreased reducing equivalents for antioxidant defense and decreased synthesis of adenosine triphosphate.

References


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