Lymphomatoid granulomatosis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kamal Akbar, M.D.[2]

Overview

Lymphomatoid granulomatosis may be classified according to a grading system into low grade and high grade.

Classification

Lymphomatoid granulomatosis may be classified according to a grading system which denotes the amount of EBV positive large B-cell malignant cells that are present. Deciphering the severity of the disease is crucial in determining which treatment options to pursue. The condition is classified into two subtypes:

• Low grade:
  • Small amount of large atypical cells
  • Few mitotic figures
  • Minute amount of necrosis
  • Some cases resolve on there own

• High grade:
  • Preponderant population of large atypical cells
  • Profuse necrosis