Lymphadenopathy risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]Raviteja Guddeti, M.B.B.S. [3]Delband Yekta Moazami, M.D.[4] Ogechukwu Hannah Nnabude, MD

Overview

Common risk factors in the development of lymphadenopathy include people at risk of infections as seen in high-risk sexual behavior for HIV,Cytomegalovirus, IV drug users, recent blood transfusion. HIV is a lymphotropic virus that activates lymph node remodeling. Lymph nodes that clinically manifest as persistent at a pathological stage Three distinct stages of lymphadenopathy include stage I, explosive follicular disease Big germinal centers of hyperplasia, stage II, germinal centers depletion of lymphocytes and central involution, and step III, proliferation Within the lymph nodes, blood vessels

Risk Factors

Common Risk Factors

• Common risk factors in the development of lymphadenopathy may be occupational, environmental, genetic, and viral.
• Common risk factors in the development of lymphadenopathy include:
  • High risk sexual behaviour - HIV/AIDS, Hepatitis B, Herpes simplex, Cytomegalovirus
  • I.V drug abuse- HIV/ AIDS, Hepatitis B, Endocarditis
  • Local soft-tissue infections
  • Upper respiratory tract infection

Less Common Risk Factors

• Less common risk factors in the development of lymphadenopathy include:
  • Recent blood transfusion- Cytomegalovirus, HIV/ AIDS
  • Eating under cooked meat- Toxoplasmosis