|Linus Pauling in 1954|
Linus Pauling in 1954
|Born||February 28 1901|
Portland, Oregon, U.S. Brownsburg Indiana
|Died||August 19 1994 (aged 93)|
Big Sur, California, U.S.
|Institutions||Caltech, UCSD, Stanford|
|Alma mater||Oregon Agricultural College, Caltech|
|Doctoral advisor||Roscoe G. Dickinson|
|Doctoral students||Jerry Donohue|
|Known for||Elucidating the nature of chemical bonds and the structures of molecules.|
Advocating nuclear disarmament.
|Notable awards|| Nobel Prize for Chemistry (1954)|
Nobel Peace Prize (1962)
|Religious stance||Raised Lutheran, Unitarian Universalist, atheist as an adult|
Linus Carl Pauling (February 28, 1901 – August 19, 1994) was an American quantum chemist and biochemist. He was also acknowledged as a crystallographer, molecular biologist, and medical researcher. Pauling is regarded by many as the premier chemist of the twentieth century, especially for the versatility of his contributions. He pioneered the application of quantum mechanics to chemistry, and in 1954 was awarded the Nobel Prize in chemistry for his work describing the nature of chemical bonds. He also made important contributions to crystal and protein structure determination, and was one of the founders of molecular biology. He came near to discovering the "double helix," the ultrastructure of DNA, which Watson and Crick discovered in 1953. Pauling is noted as a versatile scholar for his expertise in inorganic chemistry, organic chemistry, metallurgy, immunology, anesthesiology, psychology, debate, radioactive decay, and the aftermath of nuclear warfare, in addition to quantum mechanics and molecular biology.
Pauling received the Nobel Peace Prize in 1962 for his campaign against above-ground nuclear testing, and is the only person to win two Nobel prizes that were not shared with another recipient. The other people who have received two Nobel prizes are Marie Curie (physics and chemistry), John Bardeen (both in physics) and Frederick Sanger (both in chemistry). Later in life, he became an advocate for greatly increased consumption of vitamin C and other nutrients. He generalized his ideas to define orthomolecular medicine, which is still regarded as unorthodox by conventional medicine. He popularized his concepts, analyses, research and insights in several successful but controversial books centered around vitamin C and orthomolecular medicine.
Pauling was born in Portland, Oregon to Herman Henry William Pauling (1876–1910) of Concordia, Missouri; and Lucy Isabelle Darling (1881–1926) of Lonerock, Oregon. Herman was an unsuccessful druggist who moved his family to and from a number of different cities in Oregon from 1903 to 1909, finally returning to Portland that year. Herman died of a perforated ulcer in 1910, and Isabelle was left to care for Linus and two younger siblings, Pauline Pauling (1901-2003) and Lucille Pauling (1904–1973).
Linus was a voracious reader as a child, and at one point his father wrote a letter to a local paper inviting suggestions of additional books to occupy his time. A friend, Lloyd Jeffress, had a small chemistry laboratory in his bedroom when Pauling was in grammar school, and Jeffress' laboratory experiments inspired Pauling to plan to become a chemical engineer. In high school, Pauling continued to experiment in chemistry, borrowing much of the equipment and materials from an abandoned steel plant near which his grandfather worked as a night watchman.
Pauling was not allowed to take a required American history course and did not qualify for his high school diploma a year early. The school awarded him the diploma 45 years later after he had won two Nobel Prizes.
In 1917, Pauling entered the Oregon Agricultural College (OAC) in Corvallis, now Oregon State University. While at OAC, Pauling was a founding father of the Oregon State chapter of the Delta Upsilon fraternity. Because of financial needs, he had to work full-time while attending a full schedule of classes. After his second year, he planned to take a job in Portland to help support his mother, but the college offered him a position teaching quantitative analysis (a course Pauling had just finished taking as a student). This allowed him to continue his studies at OAC.
In his last two years at OAC, Pauling became aware of the work of Gilbert N. Lewis and Irving Langmuir on the electronic structure of atoms and their bonding to form molecules. He decided to focus his research on how the physical and chemical properties of substances are related to the structure of the atoms of which they are composed, becoming one of the founders of the new science of quantum chemistry.
In 1922, Pauling graduated from OAC with a degree in chemical engineering and went on to graduate school at the California Institute of Technology ("Caltech") in Pasadena, California, under the guidance of Roscoe G. Dickinson. His graduate research involved the use of X-ray diffraction to determine the structure of crystals. He published seven papers on the crystal structure of minerals while he was at Caltech. He received his Ph. D. in physical chemistry and mathematical physics, summa cum laude, in 1925.
During his senior year, Pauling taught junior classes in "Chemistry for Home Economic Majors". In one of those classes he met Ava Helen Miller, whom he married on June 17, 1923; they had a daughter (Linda) and three sons (Crellin, Linus, Peter).
Pauling had first been exposed to the concepts of quantum theory and quantum mechanics while he was studying at Oregon Agricultural College. He later traveled to Europe on a Guggenheim Fellowship to study under German physicist Arnold Sommerfeld in Munich, Danish physicist Niels Bohr in Copenhagen, and Austrian physicist Erwin Schrödinger in Zürich. All three were experts working in the new field of quantum mechanics and other branches of physics. Pauling became interested in seeing how quantum mechanics might be applied in his chosen field of interest, the electronic structure of atoms and molecules. In Europe, Pauling was also exposed to one of the first quantum mechanical analyses of bonding in the hydrogen molecule, done by Walter Heitler and Fritz London. Pauling devoted the two years of his European trip to this work and decided to make it the focus of his future research. He became one of the first scientists in the field of quantum chemistry and a pioneer in the application of quantum theory to the structure of molecules.
In 1927, Pauling took a new position as an assistant professor at Caltech in theoretical chemistry. He launched his faculty career with a very productive five years, continuing with his X-ray crystal studies and also performing quantum mechanical calculations on atoms and molecules. He published approximately fifty papers in those five years, and created five rules now known as Pauling's Rules. By 1929, he was promoted to associate professor, and by 1930, to full professor. In 1931, the American Chemical Society awarded Pauling the Langmuir Prize for the most significant work in pure science by a person 30 years of age or younger. The following year, Pauling published what he regarded as his most important paper, in which he first laid out the concept of hybridization of atomic orbitals and analyzed the tetravalency of the carbon atom.
At Caltech, Pauling struck up a close friendship with theoretical physicist Robert Oppenheimer, who was spending part of his research and teaching schedule away from U.C. Berkeley at Caltech every year. The two men planned to mount a joint attack on the nature of the chemical bond: apparently Oppenheimer would supply the mathematics and Pauling would interpret the results. However, their relationship soured when Pauling began to suspect that Oppenheimer was becoming too close to Pauling's wife, Ava Helen. Once, when Pauling was at work, Oppenheimer had come to their place and blurted out an invitation to Ava Helen to join him on a tryst in Mexico. Although she flatly refused, she reported the incident to Pauling. That, and her apparent nonchalance about the incident, disquieted him, and he immediately cut off his relationship with Oppenheimer, resulting in a coolness between them that would last their lives. Although Oppenheimer later invited Pauling to be the head of the Chemistry Division of the atomic bomb project, Pauling refused, saying that he was a pacifist.
In the summer of 1930, Pauling made another European trip, during which he learned about the use of electrons in diffraction studies similar to the ones he had performed with X-rays. After returning, he built an electron diffraction instrument at Caltech with a student of his, L. O. Brockway, and used it to study the molecular structure of a large number of chemical substances.
Pauling introduced the concept of electronegativity in 1932. Using the various properties of molecules, such as the energy required to break bonds and the dipole moments of molecules, he established a scale and an associated numerical value for most of the elements — the Pauling Electronegativity Scale — which is useful in predicting the nature of bonds between atoms in molecules.
The nature of the chemical bond
In the 1930s he began publishing papers on the nature of the chemical bond, leading to his famous textbook on the subject published in 1939. It is based primarily on his work in this area that he received the Nobel Prize in Chemistry in 1954 "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances". Pauling summarized his work on the chemical bond in The Nature of the Chemical Bond, one of the most influential chemistry books ever published. In the 30 years since its first edition was published in 1939, the book had been cited more than 16,000 times. Even today, many modern scientific papers and articles in important journals cite this work, more than half a century after first publication.
Part of Pauling's work on the nature of the chemical bond led to his introduction of the concept of orbital hybridization. While it is normal to think of the electrons in an atom as being described by orbitals of types such as s, p, etc., it turns out that in describing the bonding in molecules, it is better to construct functions that partake of some of the properties of each. Thus the one 2s and three 2p orbitals in a carbon atom can be combined to make four equivalent orbitals (called sp³ hybrid orbitals), which would be the appropriate orbitals to describe carbon compounds such as methane, or the 2s orbital may be combined with two of the 2p orbitals to make three equivalent orbitals (called sp² hybrid orbitals), with the remaining 2p orbital unhybridized, which would be the appropriate orbitals to describe certain unsaturated carbon compounds such as ethylene. Other hybridization schemes are also found in other types of molecules.
Another area which he explored was the relationship between ionic bonding, where electrons are transferred between atoms, and covalent bonding where electrons are shared between atoms on an equal basis. Pauling showed that these were merely extremes, between which most actual cases of bonding fall. It was here especially that Pauling's electronegativity concept was particularly useful; the electronegativity difference between a pair of atoms will be the surest predictor of the degree of ionicity of the bond.
The third of the topics that Pauling attacked under the overall heading of "the nature of the chemical bond" was the accounting of the structure of aromatic hydrocarbons, particularly the prototype, benzene. The best description of benzene had been made by the German chemist Friedrich Kekulé. He had treated it as a rapid interconversion between two structures, each with alternating single and double bonds, but with the double bonds of one structure in the locations where the single bonds were in the other. Pauling showed that a proper description based on quantum mechanics was an intermediate structure which was a blend of each. The structure was a superposition of structures rather than a rapid interconversion between them. The name "resonance" was later applied to this phenomenon. In a sense, this phenomenon resembles that of hybridization, described earlier, because it involves combining more than one electronic structure to achieve an intermediate result.
Structure of the atomic nucleus
On September 16, 1952, Linus Pauling opened a new research notebook with these words "I have decided to attack the problem of the structure of nuclei" (see his actual notes at Oregon State Special Collections). On October 15, 1965, Pauling published his Close-Packed Spheron Model of the atomic nucleus in two well respected journals, Science, and Proc. Natl. Acad. Sci. For nearly three decades, until his death in 1994, Pauling published numerous papers on his spheron cluster model.      
Few modern text books on nuclear physics discuss the Pauling Spheron Model of the Atomic Nucleus, yet it provides a unique perspective, well published in the leading journals of science, on how fundamental "clusters of nucleons" can form shell structure in agreement with recognized theory of quantum mechanics. Pauling was well versed in quantum mechanics--he coauthored one of the first textbooks on the subject (Introduction to Quantum Mechanics with Applications to Chemistry by Linus Pauling, E. Bright Wilson, 1935). In a 2006 review of models of atomic nuclei (Norman D. Cook, Models of the Atomic Nucleus, 2006, Springer) the author has this to say about the Pauling Spheron Model "...the model leads to a rather common-sense molecular build-up of nuclei and has an internal logic that is hard to deny...however...nuclear theorists have not elaborated on the idea of nucleon spherons, and Pauling's model has not entered mainstream nuclear theory". It is noteworthy that the 1965 Pauling Spheron Model of the atomic nucleus has not been replaced by a better model, but has simply been ignored.
The Pauling spheron nucleon clusters include the deuteron[NP], helion [PNP], and triton [NPN]. Even-even nuclei were described as being composed of clusters of alpha particles, as has often been done for light nuclei. He made an effort to derive the shell structure of nuclei from the Platonic solids rather than starting from an independent particle model as in the usual shell model. It was sometimes said at that time that this work received more attention than it would have if it had been done by a less famous person, but more likely Pauling was taking a unique approach to understanding the relatively new discovery in the late 1940s of Maria Goeppert-Mayer of structure within the nucleus. In an interview Pauling commented on his model..."Now recently, I have been trying to determine detailed structures of atomic nuclei by analyzing the ground state and excited state vibrational bends, as observed experimentally. From reading the physics literature, Physical Review Letters and other journals, I know that many physicists are interested in atomic nuclei, but none of them, so far as I have been able to discover, has been attacking the problem in the same way that I attack it. So I just move along at my own speed, making calculations..."
In the mid-1930s, Pauling decided to strike out into new areas of interest. Early in his career, he was uninterested in studying molecules of biological importance. But as Caltech was developing a new strength in biology, and Pauling interacted with such great biologists as Thomas Hunt Morgan, Theodosius Dobzhanski, Calvin Bridges, and Alfred Sturtevant, he changed his mind and switched to the study of biomolecules. His first work in this area involved the structure of hemoglobin. He demonstrated that the hemoglobin molecule changes structure when it gains or loses an oxygen atom. As a result of this observation, he decided to conduct a more thorough study of protein structure in general. He returned to his earlier use of X-ray diffraction analysis. But protein structures were far less amenable to this technique than the crystalline minerals of his former work. The best X-ray pictures of proteins in the 1930s had been made by the British crystallographer William Astbury, but when Pauling tried, in 1937, to account for Astbury's observations quantum mechanically, he could not.
It took eleven years for Pauling to explain the problem: his mathematical analysis was correct, but Astbury's pictures were taken in such a way that the protein molecules were tilted from their expected positions. Pauling had formulated a model for the structure of hemoglobin in which atoms were arranged in a helical pattern, and applied this idea to proteins in general.
In 1951, based on the structures of amino acids and peptides and the planarity of the peptide bond, Pauling and colleagues correctly proposed the alpha helix and beta sheet as the primary structural motifs in protein secondary structure. This work exemplified his ability to think unconventionally; central to the structure was the unorthodox assumption that one turn of the helix may well contain a non-integral number of amino acid residues.
Pauling then suggested a helical structure for deoxyribonucleic acid (DNA); however, his model contained several basic mistakes, including a proposal of neutral phosphate groups, an idea that conflicted with the acidity of DNA. Sir Lawrence Bragg had been disappointed that Pauling had won the race to find the alpha helix. Bragg's team had made a fundamental error in making their models of protein by not recognizing the planar nature of the peptide bond. When it was learned at the Cavendish Laboratory that Pauling was working on molecular models of the structure of DNA, Watson and Crick were allowed to make a molecular model of DNA using unpublished data from Maurice Wilkins and Rosalind Franklin at King's College. Early in 1953 James D. Watson and Francis Crick proposed a correct structure for the DNA double helix. One of the impediments facing Pauling in this work was that he did not have access to the high quality X-ray diffraction photographs of DNA taken by Rosalind Franklin, which Watson and Crick had seen. He planned to attend a conference in England, where he might have been shown the photos, but he could not do so because his passport was withheld at the time by the State Department, on suspicions that he had Communist sympathies. This was at the start of the McCarthy period in the United States.
Pauling also studied enzyme reactions and was among the first ones to point out that enzymes bring about reactions by stabilizing the transition state of the reaction, a view which is central to understanding their mechanism of action. He was also among the first scientists to postulate that the binding of antibodies to antigens would be due to a complementarity between their structures. Along the same lines, with the physicist turned biologist Max Delbruck, he wrote an early paper arguing that DNA replication was likely to be due to complementarity, rather than similarity, as suggested by a few researchers. This was made clear in the model of the structure of DNA that Watson and Crick discovered.
In November 1949, Linus Pauling, Harvey Itano, S. J. Singer and Ibert Wells published in the journal Science the first proof of a human disease caused by an abnormal protein. Using electrophoresis, they demonstrated that individuals with sickle cell disease had a modified form of hemoglobin in their red blood cells, and that individuals with sickle cell trait had both the normal and abnormal forms of hemoglobin. This was also the first demonstration that Mendelian inheritance determined the specific physical properties of proteins, not simply their presence or absence — the dawn of molecular genetics.
Pauling had been practically apolitical until World War II, but the war changed his life profoundly, and he became a peace activist. During the beginning of the Manhattan Project, Robert Oppenheimer invited him to be in charge of the Chemistry division of the project, but he declined, saying that he was a pacifist. In 1946, he joined the Emergency Committee of Atomic Scientists, chaired by Albert Einstein; its mission was to warn the public of the dangers associated with the development of nuclear weapons. His political activism prompted the U.S. State Department to deny him a passport in 1952, when he was invited to speak at a scientific conference in London. His passport was restored in 1954, shortly before the ceremony in Stockholm where he received his first Nobel Prize. Joining Einstein, Bertrand Russell and eight other leading scientists and intellectuals, he signed the Russell-Einstein Manifesto in 1955.
In 1957, Pauling began a petition drive in cooperation with biologist Barry Commoner, who had studied radioactive strontium-90 in the baby teeth of children across North America and concluded that above-ground nuclear testing posed public health risks in the form of radioactive fallout. He also participated in a public debate with the atomic physicist Edward Teller about the actual probability of fallout causing mutations. In 1958, Pauling and his wife presented the United Nations with a petition signed by more than 11,000 scientists calling for an end to nuclear-weapon testing. Public pressure subsequently led to a moratorium on above-ground nuclear weapons testing, followed by the Partial Test Ban Treaty, signed in 1963 by John F. Kennedy and Nikita Khrushchev. On the day that the treaty went into force, the Nobel Prize Committee awarded Pauling the Nobel Peace Prize, describing him as "Linus Carl Pauling, who ever since 1946 has campaigned ceaselessly, not only against nuclear weapons tests, not only against the spread of these armaments, not only against their very use, but against all warfare as a means of solving international conflicts." Interestingly, the Caltech Chemistry Department, wary of his political views, did not even formally congratulate him. However, the Biology Department did throw him a small party, showing they were more appreciative and sympathetic toward his work on radiation mutation.
Many of Pauling's critics, including scientists who appreciated the contributions that he had made in chemistry, disagreed with his political positions and saw him as a naïve spokesman for Soviet communism. He was ordered to appear before the Senate Internal Security Subcommittee, which termed him "the number one scientific name in virtually every major activity of the Communist peace offensive in this country." An extraordinary headline in Life magazine characterized his 1962 Nobel Prize as "A Weird Insult from Norway". Pauling was awarded the International Lenin Peace Prize by the USSR in 1970.
Development of the electric car
In the late 1950s, Pauling became concerned with the problem of air pollution—particularly with the growing smog problem in Los Angeles. At the time, most scientists believed that the smog was due to chemical plants and refineries, not gasoline engine exhaust. Pauling worked with Arie Haagen-Smit and others at Caltech to show that smog was a product of automobile pollution instead of factory pollution. Shortly after this discovery, Pauling began work to develop a practical and affordable electric car. He joined forces with the engineers at the Eureka Williams company in the development of the Henney Kilowatt—the first speed-controlled electric car. After researching the electrophysics underlying the initial Kilowatt propulsion system, Pauling determined that traditional lead-acid batteries would not provide the power necessary to give electric cars the performance necessary to rival traditional gasoline powered cars. Pauling accurately predicted that the low top speed and the short range of the Henney Kilowatt would make them impractical and unpopular. Pauling insisted on making the car more practical before releasing it to the public, and recommended that the project be discontinued until the appropriate battery was available commercially. Unfortunately, the Eureka Williams Company insisted that production plans for the car proceed; as Pauling predicted, the model experienced dismal sales.
Molecular medicine and medical research
In 1941, at age 40, Pauling was diagnosed with a serious form of Bright’s disease, a fatal renal disease. Experts believed then that Bright's disease was untreatable. With the help of Dr. Thomas Addis at Stanford, Pauling was able to control the disease with Addis' then unusual, low protein, salt-free diet. Addis also prescribed vitamins and minerals for all his patients.
In 1951, Pauling gave a lecture entitled, "Molecular Medicine". In the late 1950s, Pauling worked on the role of enzymes in brain function, believing that mental illness may be partly caused by enzyme dysfunction. It wasn't until he read "Niacin Therapy in Psychiatry" by Abram Hoffer in 1965 that he realized that vitamins might have important biochemical effects unrelated to their prevention of associated deficiency diseases. Pauling published a brief paper, "Orthomolecular Psychiatry", in the journal Science in 1968 (PMID 5641253) that gave name and principle to the popular but controversial megavitamin therapy movement of the 1970s. Pauling coined the term "orthomolecular" to refer to the practice of varying the concentration of substances normally present in the body to prevent and treat disease. His ideas formed the basis of orthomolecular medicine, which is not generally practiced by conventional medical professionals and is strongly criticized by some.
Pauling's work on vitamin C in his later years generated controversy and was originally regarded by some adversaries in the field of medicine as outright quackery. He was first introduced to the concept of high-dose vitamin C by biochemist Irwin Stone in 1966 and began taking several grams every day to prevent colds. Excited by the results, he researched the clinical literature and published "Vitamin C and the Common Cold" in 1970. He began a long clinical collaboration with the British cancer surgeon, Ewan Cameron, in 1971 on the use of intravenous and oral vitamin C as cancer therapy for terminal patients. Cameron and Pauling wrote many technical papers and a popular book, "Cancer and Vitamin C", that discussed their observations. Three prospective, randomized, placebo-controlled trials were conducted by Moertel et al. at the Mayo Clinic; all three failed to prove a benefit for megadoses of vitamin C in cancer patients. Pauling denounced Charles Moertel's conclusions and handling of the final study as "fraud and deliberate misrepresentation." Pauling then published critiques of the second Mayo-Moertel cancer trial's flaws over several years as he was able to slowly unearth some of the trial's undisclosed details. However, the wave of adverse publicity generated by Moertel and the media effectively undercut Pauling's credibility and his vitamin C work for a generation, the oncological mainstream continued with other avenues of treatment. Always precariously perched since his molecular biologically inspired crusade to stop atmospheric nuclear testing in the 1950s, the 1985 Mayo-Moertel confrontation left Pauling isolated from his institutional funding sources, academic support and a bemused public. He later collaborated with the Canadian physician, Abram Hoffer, on a micronutrient regimen, including high-dose vitamin C, as adjunctive cancer therapy.
As of 2006, new evidence of high-dose Vitamin C efficacy was proposed by a Canadian group of researchers. These researchers observed longer-than expected survival times in three patients treated with high doses of intravenous Vitamin C. The researchers are reportedly planning a new Phase I clinical trial  The selective toxicity of vitamin C for cancer cells has been demonstrated in-vitro (i.e., in a cell culture Petri dish), and was reported in 2005.  The combination of case-report data and preclinical information suggest biological plausibility and the possibility of clinical efficacy at the possible expense of critical toxicity at active doses; future clinical testing will ultimately determine the utility and safety of intravenous high-dose Vitamin C treatments for patients with cancer. Researchers released a paper demonstrating in-vitro vitamin C killing of cancer cells in The Proceedings of the National Academy of Sciences in 2006.
With two colleagues, Pauling founded the Institute of Orthomolecular Medicine in Menlo Park, California, in 1973, which was soon renamed the Linus Pauling Institute of Science and Medicine. Pauling directed research on vitamin C, but also continued his theoretical work in chemistry and physics until his death. In his last years, he became especially interested in the possible role of vitamin C in preventing atherosclerosis and published three case reports on the use of lysine and vitamin C to relieve angina pectoris. In 1996, the Linus Pauling Institute moved from Palo Alto, California, to Corvallis, Oregon, to become part of Oregon State University, where it continues to conduct research on micronutrients, phytochemicals (chemicals from plants), and other constituents of the diet in preventing and treating disease. Several of the employees that had previously worked at the Linus Pauling Institute in Palo Alto moved on to form the Genetic Information Research Institute.
Pauling's contribution to science is held by many in the utmost regard. He was included in a list of the 20 greatest scientists of all time by the British magazine New Scientist, with Albert Einstein being the only other scientist from the twentieth century on the list. Gautam R. Desiraju, the author of the Millennium Essay in Nature, claimed that Pauling was one of the greatest thinkers and visionaries of the millennium, along with Galileo, Newton, and Einstein. Pauling is also notable for the diversity of his interests: quantum mechanics, inorganic chemistry, organic chemistry, protein structure, molecular biology, and medicine. In all these fields, and especially on the boundaries between them, he made decisive contributions. His work on chemical bonding marks the beginning of modern quantum chemistry, and many of his contributions like hybridization and electronegativity have become part of standard chemistry textbooks. Although his valence bond approach fell short of accounting quantitatively for some of the characteristics of molecules, such as the paramagnetic nature of oxygen and the color of organometallic complexes, and would later be superseded by the Molecular Orbital Theory of Robert Mulliken, the strength of Pauling's theory has lain in its simplicity, and it has endured. Nowadays the Valence Bond theory still exists in its modern form and competes with the Molecular Orbital Theory and Density Functional Theory (DFT) for describing the chemical phenomena . Pauling's work on crystal structure contributed significantly to the prediction and elucidation of the structures of complex minerals and compounds. His discovery of the alpha helix and beta sheet is a fundamental foundation for the study of protein structure.
In his time, Pauling was frequently honored with the sobriquet "Father of molecular biology", a contribution acknowledged by Francis Crick. His discovery of sickle cell anemia as a 'molecular disease' opened the way toward examining genetically acquired mutations at a molecular level.
Though the scientific community at large did not agree with Pauling's conclusions in his vitamin-related medical research and writing, his entry into the fray gave a larger voice in the public mind to nutrients such as vitamins and minerals for disease prevention. Specifically, his protege Dr Mathias Rath, MD, continued his early works into Cellular Medicine, expanding the volumes of data about natural substances related in disease prevention and alleviation. Pauling's stand also led these subjects to be much more actively investigated by other researchers, including those at the Linus Pauling Institute which lists a dozen principal investigators and faculty who explore the role of micronutrients, plus phytochemicals, in health and disease.
Honours and awards
- 1931 Langmuir Prize, American Chemical Society
- 1941 Nichols Medal, New York Section, American Chemical Society
- 1947 Davy Medal, Royal Society
- 1948 United States Presidential Medal for Merit
- 1952 Pasteur Medal, Biochemical Society of France
- 1954 Nobel Prize, Chemistry
- 1955 Addis Medal, National Nephrosis Foundation
- 1955 Phillips Memorial Award, American College of Physicians
- 1956 Avogadro Medal, Italian Academy of b,la
- 1957 Paul Sabatier Medal
- 1957 Pierre Fermat Medal in Mathematics
- 1957 International Grotius Medal
- 1962 Nobel Peace Prize
- 1965 Republic of Italy
- 1965 Medal, Academy of the Rumanian People's Republic
- 1966 Linus Pauling Medal
- 1966 Silver Medal, Institute of France
- 1966 Supreme Peace Sponsor, World Fellowship of Religion
- 1972 United States National Medal of Science
- 1972 International Lenin Peace Prize
- 1977 Lomonosov Gold Medal, USSR Academy of Science
- 1979 Medal for Chemical Sciences, National Academy of Science
- 1984 Priestley Medal, American Chemical Society
- 1984 Award for Chemistry, Arthur M. Sackler Foundation
- 1987 Award in Chemical Education, American Chemical Society
- 1989 Vannevar Bush Award, National Science Board
- 1990 Richard C. Tolman Medal, Southern California, Section, American Chemical Society
- Linus Pauling was a member of Delta Upsilon Fraternity.
- Linus Pauling was a member of the Alpha Chi Sigma professional chemistry fraternity.
- Linus Pauling was raised as member of the Lutheran Church
- Linus Pauling later joined Unitarian Universalist Church and declared publicly his atheist belief
- Linus Pauling was a member of Sigma Xi, The Scientific Research Society and a founder-member of the Society's Caltech chapter.
- After becoming convinced of its worth, Linus Pauling took 10 grams of vitamin C per day. 
- There is a Houston, Texas, psych-rock band called the Linus Pauling Quartet.
- In Corvallis, Oregon, USA, a new middle school was named Linus Pauling Middle School in 2003.
- Linus Torvalds, creator of Linux, is named after Pauling. 
- Pauling Field - located in Condon, Oregon - is named after Linus Pauling. Dr. Pauling spent his youth in Condon.
Works by Linus Pauling
- Pauling, L. The Nature of the Chemical Bond (Cornell University Press) ISBN 0-8014-0333-2
- Pauling, L., and Wilson, E. B. Introduction to Quantum Mechanics with Applications to Chemistry (Dover Publications) ISBN 0-486-64871-0
- Cameron E. and Pauling, L. Cancer and Vitamin C: A Discussion of the Nature, Causes, Prevention, and Treatment of Cancer With Special Reference to the Value of Vitamin C (Camino Books) ISBN 0-940159-21-X
- Pauling, L. How to Live Longer and Feel Better (Avon Books) ISBN 0-380-70289-4
- Pauling, L. Linus Pauling On Peace - A Scientist Speaks Out on Humanism and World Survival (Rising Star Press) ISBN 0-933670-03-6
- Pauling, L. General Chemistry (Dover Publications) ISBN 0-486-65622-5
- A Lifelong Quest for Peace with Daisaku Ikeda
- Pauling, L. The Architecture of Molecules
- Father: Herman Henry William Pauling (druggist, b. Missouri)
- Mother: Lucy Isabelle Darling (b. Oregon)
- Wife: Ava Helen Miller (b. Beaver Creek OR, m. 1923)
- Son: Linus Carl Pauling, Jr. (b. 1925) living in Honolulu
- Son: Peter Jeffress Pauling (1931-2003), a crystallographer and retired lecturer in chemistry. Resided in Wales until his death
- Daughter: Linda Helen Pauling (b. 1932)
- Son: Edward Crellin Pauling (1937-1997) was a professor of biology at San Francisco State University and The University of California, Riverside campus
- Great Grandson: Lucas Carl Pauling (b. 1987)
- There are 15 grandchildren and 21 great-grandchildren
- Great grand-daughters Natasha and Maja Pauling currently live in London, UK
- "A couple of days after my talk, there was a man in my office from the FBI saying, 'Who told you how much plutonium there is in an atomic bomb?' And I said 'Nobody told me, I figured it out.'"
- "I have always liked working in some scientific direction that nobody else is working in."
- "Perhaps as one of the older generation, I should preach a little sermon to you, but I do not propose to do so. I shall, instead, give you a word of advice about how to behave toward your elders. When an old and distinguished person speaks to you, listen to him carefully and with respect – but do not believe him. Never put your trust in anything but your own intellect. Your elder, no matter whether he has gray hair or lost his hair, no matter whether he is a Nobel Laureate, may be wrong... So you must always be skeptical – always think for yourself."
- "Well, you just have lots of ideas and throw away the bad ones. You aren't going to have good ideas, unless you have lots of ideas and some principle of selection."
- "'You should recognize,' he [Roscoe Gilkey Dickinson] said to me, 'that there is in almost every investigation a lack of complete rigor. You should understand just how reliable the arguments are that you are presenting.'"
- Alpha helix
- Megavitamin therapy
- Orthomolecular medicine
- Pauling's rules
- Vitamin C
- 1920 US Census with Pauling in Portland, Oregon
- Hager, Thomas, Force of Nature: The Life of Linus Pauling, Simon & Schuster (1995) ISBN 0-684-80909-5.
- Hager, Tom, Linus Pauling and the Chemistry of Life, Oxford University Press (1998) ISBN 0-19-513972-0.
- Mead, Clifford and Thomas Hager, Linus Pauling: Scientist and Peacemaker, Oregon State University Press (2001) ISBN 0-87071-489-9.
- Marinacci, Barbara, and Ramesh Krishnamurthy, Linus Pauling on Peace, Rising Star Press (1998) ISBN 0-933670-03-6.
- Goertzel, Ted and Ben Goertzel, Linus Pauling: A Life in Science and Politics, Basic Books (1995) ISBN 0-465-00672-8
- Serafini, Anthony, Linus Pauling: A Man and His Science, Paragon House (1989) ISBN 1-55778-440-X.
- "Linus Pauling Biography". Elsevier Publishing Company. 1972. Retrieved 2007-08-05.
- Linus Pauling Institute. "Linus Pauling: A Biographical Timeline". Retrieved 2007-08-05.
- Pauling, Linus (October 1965). "The close-packed-spheron theory and nuclear fission". Science. Retrieved 2007-08-05.
- Pauling, Linus (October 1965). "The close-packed spheron model of atomic nuclei and its relation to the shell model". Science. Retrieved 2007-08-05.
- Pauling, Linus (July 1966). "The close-packed-spheron theory of nuclear structure and the neutron excess for stable nuclei (Dedicated to the seventieth anniversary of Professor Horia Hulubei)". Science. Retrieved 2007-08-05.
- Pauling, Linus (December 1967). "Magnetic-moment evidence for the polyspheron structure of the lighter atomic nuclei". Science. Retrieved 2007-08-05.
- Pauling, Linus (November 1969). "Orbiting clusters in atomic nuclei". Science. Retrieved 2007-08-05.
- Pauling, Linus (1975). "Rotating clusters in nuclei". Canadian Jouranl of Physics. Retrieved 2007-08-05. Unknown parameter
- Pauling, Linus (February 1991). "http://osulibrary.orst.edu/specialcollections/rnb/26/26-125.html". Proc. Natl. Acad. Sci. Retrieved 2007-08-05. External link in
- "Linus Pauling's DNA Model". Retrieved 2007-08-06.
- Pauling, Linus (November 1949). "Sickle Cell Anemia, a Molecular Disease". Science. Retrieved 2007-08-05. Unknown parameter
- Pauling, Linus (October 1951). "Molecular Medicine". Ava Helen and Linus Pauling Papers. Retrieved 2007-08-05.
- Cassileth, BR (1998:67). Alternative Medicine Handbook: the Complete Reference Guide to Alternative and Complementary Therapies. New York: W.W. Norton & Co. Check date values in:
- "Vitamin Therapy, Megadose / Orthomolecular Therapy". BC Cancer Agency. February 2000. Retrieved 2007-08-05.
Stephen Barrett M.D. (2001-05-05). "The Dark Side of Linus Pauling's Legacy". Quackwatch. Retrieved 2007-08-05. Check date values in:
- Ewan Cameron M.D. "Cancer bibliography". Doctoryourself.com. Retrieved 2007-08-05.
- Stephen Barrett M.D. (1999-11-07). "High Doses of Vitamin C Are Not Effective as a Cancer Treatment". Quackwatch. Retrieved 2007-08-05. Check date values in:
- Ted Goertzel (1996). "Analyzing Pauling's Personality: A Three Generational, Three Decade Project". Special Collections, Oregon State University Libraries. Retrieved 2007-08-05.
- (2005), University of Chicago Press, ISBN 0-226-11366-3, Excerpt from pages 89-111
- Mark Levine (2006-03-28). "Intravenously administered vitamin C as cancer therapy: three cases". CMA Media. Retrieved 2007-08-05. Unknown parameter
|coauthors=ignored (help); Check date values in:
- "Ibtravenous Vitamin C Kills Cancer Celld". Proc. Natl. Acad. Sci. 2005-09-12. Retrieved 2007-08-05. Unknown parameter
|coauthors=ignored (help); Check date values in:
- Collin, Harry (2007). Dr. Golem: How to Think about Medicine. Chicago: University of Chicago Press. ISBN 0226113671. Unknown parameter
- "No More War!". Linus Pauling and the Twentieth Century. Archived from the original on 2007-08-06. Retrieved 2007-08-06.
- Andrew W. Saul. "Abram Hoffer, M.D., Ph.D. 50 Years of Megavitamin Research, Practice and Publication". Doctoryourself.com. Retrieved 2007-08-05. Unknown parameter
- Padayatty S, Riordan H, Hewitt S, Katz A, Hoffer L, Levine M (2006). "Intravenously administered vitamin C as cancer therapy: three cases". CMAJ. 174 (7): 937–42. PMID 16567755.
- Assouline S, Miller W (2006). "High-dose vitamin C therapy: renewed hope or false promise?". CMAJ. 174 (7): 956–7. PMID 16567756.
- Chen Q, Espey M, Krishna M, Mitchell J, Corpe C, Buettner G, Shacter E, Levine M (2005). "Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues". Proc Natl Acad Sci U S A. 102 (38): 13604–9. PMID 16157892.
"Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues". PNAS. 2005-09-20. Retrieved 2007-08-05. Unknown parameter
|coauthors=ignored (help); Check date values in:
- Goertzel, Ted (1995). Linus Pauling: A Life in Science and Politics. New York: Basic Books. pp. p247. ISBN 0-465-00673-6. Unknown parameter
- Desiraju, G.R. (2000-11-23). "The all-chemist" (PDF). Nature. Retrieved 2007-08-05. Check date values in:
- "A Conversation on VB vs MO Theory: A Never-Ending Rivalry?". ACS Publications. 2003. pp. 750–756. Retrieved 2007-08-05. Unknown parameter
- "Vitamin C does not cause cancer. Less at 11 - Men's Fitness Takes on TV News". Men's Fitness. February 2002. Retrieved 2007-08-05.
- "Linus Torvalds: A Very Brief and Completly Unauthorized Biography". 2006-01-24. Retrieved 2007-08-05. Check date values in:
- Francis Crick: The Impact of Linus Pauling on Molecular Biology (from the 1995 Oregon State University symposium)
- The Ava Helen and Linus Pauling Papers at the Oregon State University Libraries
- The Pauling Catalogue
- Linus Pauling (1901-1994)
- National Academy of Sciences biography
- Caltech oral history interview
- Berkeley Conversations With History interview
- Scans of 46 of Linus Pauling's research notebooks from 1922 to 1994
- Linus Pauling and the Race for DNA: A Documentary History
- Linus Pauling and the Nature of the Chemical Bond: A Documentary History
- Linus Pauling, Hemoglobin and Sickle Cell Anemia: A Documentary History
- Linus Pauling's Honors, Awards and Medals
- Linus Pauling Centenary Exhibit
- Linus Pauling from The Dictionary of Unitarian and Universalist Biography
- Linus Pauling Investigates Vitamin C
- The Dark Side of Linus Pauling's Legacy
- The introduction to Linus Pauling and The Chemistry of Life
- The Linus Pauling Institute at Oregon State University and
- Biography: "Scientist for The Ages" at The Linus Pauling Institute
- The Many Lives of Linus Pauling: A Review of Reviews J. Chem. Educ.
- Pauling's CV
- Publications of Pauling
|Time's Men of the Year(Alongside Isidor Rabi, Edward Teller, Joshua Lederberg, Donald A. Glaser, Willard Libby, Robert Woodward, Charles Draper, William Shockley, Emilio Segrè, John Enders, Charles Townes, George Beadle, James Van Allen and Edward Purcell representing U.S. Scientists)
John F. Kennedy
|NAME||Pauling, Linus Carl|
|SHORT DESCRIPTION||American biochemist and theoretical chemist, anti-nuclear testing campaigner, Nobel laureate|
|DATE OF BIRTH||February 28, 1901|
|PLACE OF BIRTH||Portland, Oregon|
|DATE OF DEATH||August 19, 1994|
|PLACE OF DEATH||Big Sur, California|
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