Ipriflavone

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Ipriflavone
Gene therapy
Clinical data
Other names	3-phenyl-7-propan-2-yloxychromen-4-one
AHFS/Drugs.com	International Drug Names
ATC code	M05BX01 (WHO) ;
Physiological data
Legal status
Pharmacokinetic data
Identifiers
	IUPAC name 7-isopropoxy-3-phenyl-4H-chromen-4-one;
CAS Number	35212-22-7 ;
PubChem Template:Abbreviation	3747;
ChemSpider	3616 ;
UNII	80BJ7WN25Z;
KEGG	D01338 ;
ChEMBL	ChEMBL165790 ;
Chemical and physical data
Formula	C18H16O3
Molar mass	280.318 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC(C)OC1=CC2=C(C=C1)C(=O)C(=CO2)C3=CC=CC=C3;
	InChI InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3 ; Key:SFBODOKJTYAUCM-UHFFFAOYSA-N ;
	Template:Xmark (what is this?) (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Ipriflavone is a synthetic isoflavone which may be used to inhibit bone resorption,^[1] maintain bone density and to prevent osteoporosis in postmenopausal women. It is not used to treat osteoporosis. It slows down the action of the osteoclasts (bone-eroding cells), possibly allowing the osteoblasts (bone-building cells) to build up bone mass.

A clinical trial reported in 2001 that it was not effective in prevention or treatment of osteoporosis.^[2]

A double-blind study reveals that ipriflavone might be effective on reducing tinnitus on otosclerosis sufferers.^[3]

References

↑ Civitelli, R. (1997). "In Vitro and in Vivo effects of ipriflavone on bone formation and bone biomechanics". Calcified Tissue International. 61: S12–4. doi:10.1007/s002239900378. PMID 9263610.
↑ Alexandersen, P.; Toussaint, A; Christiansen, C; Devogelaer, JP; Roux, C; Fechtenbaum, J; Gennari, C; Reginster, JY; Ipriflavone Multicenter European Fracture Study (2001). "Ipriflavone in the Treatment of Postmenopausal Osteoporosis: A Randomized Controlled Trial". JAMA. 285 (11): 1482–8. doi:10.1001/jama.285.11.1482. PMID 11255425.
↑ Sziklai, I; Komora, V; Ribári, O (1992). "Double-blind study on the effectiveness of a bioflavonoid in the control of tinnitus in otosclerosis". Acta chirurgica Hungarica. 33 (1–2): 101–7. PMID 1343452.

External links

Ipriflavone at PDR Health

Template:Drugs for treatment of bone diseases

[pmid9263610-1] Civitelli, R. (1997). "In Vitro and in Vivo effects of ipriflavone on bone formation and bone biomechanics". Calcified Tissue International. 61: S12–4. doi:10.1007/s002239900378. PMID 9263610.

[2] Alexandersen, P.; Toussaint, A; Christiansen, C; Devogelaer, JP; Roux, C; Fechtenbaum, J; Gennari, C; Reginster, JY; Ipriflavone Multicenter European Fracture Study (2001). "Ipriflavone in the Treatment of Postmenopausal Osteoporosis: A Randomized Controlled Trial". JAMA. 285 (11): 1482–8. doi:10.1001/jama.285.11.1482. PMID 11255425.

[3] Sziklai, I; Komora, V; Ribári, O (1992). "Double-blind study on the effectiveness of a bioflavonoid in the control of tinnitus in otosclerosis". Acta chirurgica Hungarica. 33 (1–2): 101–7. PMID 1343452.

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Ipriflavone

Overview

References

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