Idiopathic pulmonary fibrosis causes

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Idiopathic pulmonary fibrosis Microchapters


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]


Common causes of pulmonary fibrosis include autoimmunity, rheumatoid arthritis, scleroderma, tuberculosis, SLE, sarocoidosis, and polymyoisitis. Other causes of pulmonary fibrosis include environmental factors as cigarette smoking and dust exposure.


Common Causes

The most common causes of pulmonary fibrosis are:[1][2]

Environmental Factors


Genetic and Inherited Diseases also make up 10-15% of idiopathic pulmonary fibrosis diagnosis.

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Methotrexate, Trexall, Cyclophosphamide, Cytoxan, Amiodarone, Cordarone, Nexterone, Pacerone, propranolol, Inderol, Innopran, Nitrofurantoin, Macrobid, Macrodantin, Sulfasalazine, Azulfidine
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental Cigarette Smoke, Asbestos, silica, Coal dust, Beryllium, heavy metal dusts, Animal proteins, Bacteria, Molds, Radiation
Gastroenterologic Gastroesophageal reflux disease
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Dermatomyositis, Polymyositis
Musculoskeletal / Ortho Rheumatoid arthritis
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Tuberculosis, Pneumonia, Anti-synthetase syndrome
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Sarcoidosis, Systemic lupus erythematosus, Rheumatoid arthritis, Lupus pleuritis
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order


  1. Olson AL, Swigris JJ (2012). "Idiopathic pulmonary fibrosis: diagnosis and epidemiology". Clin Chest Med. 33 (1): 41–50. doi:10.1016/j.ccm.2011.12.001. PMID 22365244.
  2. Williams KJ (2014). "Gammaherpesviruses and pulmonary fibrosis: evidence from humans, horses, and rodents". Vet Pathol. 51 (2): 372–84. doi:10.1177/0300985814521838. PMID 24569614.

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