Idiopathic pulmonary fibrosis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Common causes of pulmonary fibrosis include autoimmunity, rheumatoid arthritis, scleroderma, tuberculosis, SLE, sarocoidosis, and polymyoisitis. Other causes of pulmonary fibrosis include environmental factors as cigarette smoking and dust exposure.
Causes
Common Causes
The most common causes of pulmonary fibrosis are:[1][2]
- Autoimmune diseases:
- Rheumatoid arthritis
- Scleroderma (systemic sclerosis)
- Tuberculosis
- Pneumonia
- Systemic lupus erythematosus
- Sarcoidosis
- Polymyositis
- Dermatomyositis
- Anti-synthetase syndrome
- Gastroesophageal reflux disease
Environmental Factors
- Cigarette smoke
- Asbestos exposure
- Silica exposure
- Coal dust exposure
- Beryllium exposure
- Hard metal dusts exposure
- Animal protein exposure
- Bacteria, mold exposure
- Radiation
Drugs
- lomustine
- Panitumumab
- Penicillamine
- Rifapentin
- Methotrexate (Trexall)
- Cyclophosphamide (Cytoxan)
- Amiodarone (Cordarone)
- Nexterone (Pacerone)
- Propranolol (Inderol, Innopran)
- Nitrofurantoin (Macrobid, Macrodantin)
- Sulfasalazine (Azulfidine)
Genetic and Inherited Diseases also make up 10-15% of idiopathic pulmonary fibrosis diagnosis.
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical / poisoning | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Methotrexate, Trexall, Cyclophosphamide, Cytoxan, Amiodarone, Cordarone, Nexterone, Pacerone, propranolol, Inderol, Innopran, Nitrofurantoin, Macrobid, Macrodantin, Sulfasalazine, Azulfidine |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | Cigarette Smoke, Asbestos, silica, Coal dust, Beryllium, heavy metal dusts, Animal proteins, Bacteria, Molds, Radiation |
| Gastroenterologic | Gastroesophageal reflux disease |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | Dermatomyositis, Polymyositis |
| Musculoskeletal / Ortho | Rheumatoid arthritis |
| Neurologic | No underlying causes |
| Nutritional / Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Opthalmologic | No underlying causes |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | Tuberculosis, Pneumonia, Anti-synthetase syndrome |
| Renal / Electrolyte | No underlying causes |
| Rheum / Immune / Allergy | Sarcoidosis, Systemic lupus erythematosus, Rheumatoid arthritis, Lupus pleuritis |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Dental | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
- Amiodarone
- Animal protein exposure
- Anti-synthetase syndrome
- Asbestos
- Autoimmune diseases
- Azulfidine
- Bacteria
- Beryllium
- Cigarette smoke
- Coal dust exposure
- Cordarone
- Cyclophosphamide
- Cytoxan
- Dermatomyositis
- Gastroesophageal reflux disease
- Heavy metal dusts exposure
- Inderol
- Innopran
- lomustine
- Macrobid
- Macrodantin
- Methotrexate
- Mold
- Nexterone
- Nitrofurantoin
- Pacerone
- Panitumumab
- Penicillamine
- Pneumonia
- Polymyositis
- Propranolol
- Radiation
- Rheumatoid arthritis
- Rifapentin
- Sarcoidosis
- Scleroderma
- Silica exposure
- sulfasalazine
- Systemic lupus erythematosus
- systemic sclerosis
- Trexall
- Tuberculosis
References
- ↑ Olson AL, Swigris JJ (2012). "Idiopathic pulmonary fibrosis: diagnosis and epidemiology". Clin Chest Med. 33 (1): 41–50. doi:10.1016/j.ccm.2011.12.001. PMID 22365244.
- ↑ Williams KJ (2014). "Gammaherpesviruses and pulmonary fibrosis: evidence from humans, horses, and rodents". Vet Pathol. 51 (2): 372–84. doi:10.1177/0300985814521838. PMID 24569614.
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