Idiopathic infantile arterial calcification history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayokunle Olubaniyi, M.B,B.S [2]


Idiopathic arterial calcification of infancy should always be considered in infants and children presenting with hypertension, cardiac failure, or sudden death.[1] Clinical presentation is variable. First symptoms usually occur at birth but can take place in the first 6 months of life or in utero.[2]

History and Symptoms


  1. Hault, Kathrin; Sebire, Neil J.; Ho, Siew Y.; Sheppard, Mary N. (2008). "The difficulty in diagnosing idiopathic arterial calcification of infancy, its variation in presentation, and the importance of autopsy". Cardiology in the Young. 18 (6): 624–7. doi:10.1017/S1047951108003168. PMID 18842162.
  2. Chong, CR.; Hutchins, GM. "Idiopathic infantile arterial calcification: the spectrum of clinical presentations". Pediatr Dev Pathol. 11 (5): 405–15. doi:10.2350/07-06-0297.1. PMID 17990935.
  3. 3.0 3.1 Abu-Asbeh, J; Khan, J; Shallal, A (2006). "Idiopathic infantile arterial calcification associated with leukomalacia". Journal of the Arab Neonatology Forum. 3 (1): 15–9.
  4. Nagar, Arpit M.; Hanchate, Vijay; Tandon, Ankit; Thakkar, Hemangini; Chaubal, Nitin G. (2003-06-01). "Antenatal Detection of Idiopathic Arterial Calcification With Hydrops Fetalis". Journal of Ultrasound in Medicine. 22 (6): 653–9. PMID 12795564.
  5. Maayan, Ch.; Peleg, O.; Eyal, F.; Mogle, P.; Rosenmann, E.; Ziv, J. Bar (1984). "Idiopathic infantile arterial calcification: A case report and review of the literature". European Journal of Pediatrics. 142 (3): 211–5. doi:10.1007/BF00442452. PMID 6468446.
  6. Milner, Laurence S.; Heitner, René; Thomson, Peter D.; Levin, Solomon E.; Rothberg, Alan D.; Beale, Peter; Ninin, Daniel T. (1984). "Hypertension as the major problem of idiopathic arterial calcification of infancy". The Journal of Pediatrics. 105 (6): 934–8. doi:10.1016/S0022-3476(84)80080-3. PMID 6502343.
  7. Hunt, A. C.; Leys, D. G. (1957). "Generalized Arterial Calcification of Infancy". BMJ. 1 (5015): 385–6. doi:10.1136/bmj.1.5015.385. PMC 1974337. PMID 13396267.
  8. Thiaville, A.; Smets, A.; Clercx, A.; Perlmutter, N. (1994). "Idiopathic infantile arterial calcification: A surviving patient with renal artery stenosis". Pediatric Radiology. 24 (7): 506–8. doi:10.1007/BF02015014. PMID 7885787.
  9. Sharmila, N.; Prashant, S. Joshi; Ravikumar, Vani (2010). "Idiopathic Infantile arterial calcification–A Very rare case". Online Journal of Health and Allied Sciences. 9 (1). ISSN 0972-5997. Unknown parameter |month= ignored (help)
  10. 10.0 10.1 Inwald, D P; Yen Ho, S; Shepherd, M N; Daubeney, P E F (2006). "Idiopathic infantile arterial calcification presenting as fatal hypertensive cardiomyopathy". Archives of Disease in Childhood. 91 (11): 928. doi:10.1136/adc.2006.103093. PMC 2082956. PMID 17056867.
  11. Vera, J.; Lucaya, J.; Garcia Conesa, J. A.; Aso, C.; Balaguer, A. (1990). "Idiopathic infantile arterial calcification: Unusual features". Pediatric Radiology. 20 (8): 585–7. doi:10.1007/BF02129060. PMID 2251001.
  12. Conn, Jessica; Hussaini, Shaheen; Greenberg, S. Bruce; Vanderzalm, Theodora; Klein, Sarah G. "Idiopathic Arterial Calcification of Infancy" (PDF). Little Rock, Arkansas: University of Arkansas for Medical Sciences and Arkansas Children's Hospital.
  13. Levine, J. C.; Campbell, J.; Nadel, A. (2001). "Prenatal Diagnosis of Idiopathic Infantile Arterial Calcification". Circulation. 103 (2): 325–6. doi:10.1161/01.CIR.103.2.325. PMID 11208697.
  14. Sundaram, S; Kuruvilla, S; Thirupuram, S (2004). "Idiopathic arterial calcification of infancy - a case report". Images in paediatric cardiology. 6 (1): 6–12. PMC 3232550. PMID 22368635.
  15. Dlamini, Nomazulu; Splitt, Miranda; Durkan, Anne; Siddiqui, Ata; Padayachee, Soundrie; Hobbins, Sue; Rutsch, Frank; Wraige, Elizabeth (2009). "Generalized arterial calcification of infancy: Phenotypic spectrum among three siblings including one case without obvious arterial calcifications". American Journal of Medical Genetics Part A. 149A (3): 456–60. doi:10.1002/ajmg.a.32646. PMID 19206175.

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