Hereditary pancreatitis screening
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Overview
Patients with hereditary pancreatitis should be screened for pancreatic cancer as they are at markedly increased risk of pancreatic cancer.
Screening
- Patients with hereditary pancreatitis should be screened for pancreatic cancer as they are at markedly increased risk of pancreatic cancer.[1][2][3][4][5][6]
- According to 2001 guidelines, screening for pancreatic cancer should begin at age 40.[1]
- In 2007, The Fourth Annual Symposium of Inherited Diseases of the Pancreas recommended the screening age for pancreatic cancer in patients with hereditary pancreatitis or those at increased risk to be (whichever is at the earliest age)[2]
- 45 year old or
- Starting 15 years earlier than the youngest age of pancreatic cancer in the family (whichever is at the earliest age)
- Patients with hereditary pancreatitis are usually recommended for yearly screening for pancreatic exocrine and endocrine insufficiency.
References
- ↑ 1.0 1.1 Ulrich CD (2001). "Pancreatic cancer in hereditary pancreatitis: consensus guidelines for prevention, screening and treatment". Pancreatology. 1 (5): 416–22. PMID 12120218.
- ↑ 2.0 2.1 Brand RE, Lerch MM, Rubinstein WS, Neoptolemos JP, Whitcomb DC, Hruban RH, Brentnall TA, Lynch HT, Canto MI (2007). "Advances in counselling and surveillance of patients at risk for pancreatic cancer". Gut. 56 (10): 1460–9. doi:10.1136/gut.2006.108456. PMC 2000231. PMID 17872573.
- ↑ Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, Truninger K, Ammann R, Cavallini G, Charnley RM, Uomo G, Delhaye M, Spicak J, Drumm B, Jansen J, Mountford R, Whitcomb DC, Neoptolemos JP (2004). "Clinical and genetic characteristics of hereditary pancreatitis in Europe". Clin. Gastroenterol. Hepatol. 2 (3): 252–61. PMID 15017610.
- ↑ Rebours V, Boutron-Ruault MC, Schnee M, Férec C, Le Maréchal C, Hentic O, Maire F, Hammel P, Ruszniewski P, Lévy P (2009). "The natural history of hereditary pancreatitis: a national series". Gut. 58 (1): 97–103. doi:10.1136/gut.2008.149179. PMID 18755888.
- ↑ Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK, Perrault J, Whitcomb DC (1997). "Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group". J. Natl. Cancer Inst. 89 (6): 442–6. PMID 9091646.
- ↑ Whitcomb DC, Applebaum S, Martin SP (1999). "Hereditary pancreatitis and pancreatic carcinoma". Ann. N. Y. Acad. Sci. 880: 201–9. PMID 10415865.