Hairy cell leukemia diagnotic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

Peripheral blood smears are the gold standard test for the diagnosis of hairy cell leukemia.

Peripheral blood smear is one of the gold standard tests for the diagnosis of hairy cell leukemia.^[1]

The following result of peripheral blood smears is confirmatory of hairy cell leukemia:

Oval nuclei and abundant cytoplasm with "hairy" projections
"Fried egg" appearance
Loose chromatin
Mast cells numbers elevate
Extravasated red cells are positive in peripheral blood smear of hairy cell leukemia patients

↑ Burke JS, Rappaport H (December 1984). "The diagnosis and differential diagnosis of hairy cell leukemia in bone marrow and spleen". Semin. Oncol. 11 (4): 334–46. PMID 6505703.