FBP1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Fructose-1,6-bisphosphatase 1 is a protein that in humans is encoded by the FBP1 gene.

Function

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.

Further reading

• Yáñez AJ, Bertinat R, Spichiger C, Carcamo JG, de Los Angeles García M, Concha II, Nualart F, Slebe JC (Oct 2005). "Novel expression of liver FBPase in Langerhans islets of human and rat pancreas". Journal of Cellular Physiology. 205 (1): 19–24. doi:10.1002/jcp.20407. PMID 15965961.
• Faiyaz-Ul-Haque M, Al-Owain M, Al-Dayel F, Al-Hassnan Z, Al-Zaidan H, Rahbeeni Z, Al-Sayed M, Balobaid A, Cluntun A, Toulimat M, Abalkhail H, Peltekova I, Zaidi SH (Dec 2009). "Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency". European Journal of Pediatrics. 168 (12): 1467–71. doi:10.1007/s00431-009-0953-9. PMID 19259699.
• Kikawa Y, Inuzuka M, Takano T, Shigematsu Y, Nakai A, Yamamoto Y, Jin BY, Koga J, Taketo A, Sudo M (Mar 1994). "cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency". Biochemical and Biophysical Research Communications. 199 (2): 687–93. doi:10.1006/bbrc.1994.1283. PMID 8135811.
• Besançon F, Just J, Bourgeade MF, Van Weyenbergh J, Solomon D, Guillozo H, Wietzerbin J, Cayre YE (Aug 1997). "HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase". Journal of Interferon & Cytokine Research. 17 (8): 461–7. doi:10.1089/jir.1997.17.461. PMID 9282826.
• Gizak A, Maciaszczyk-Dziubinska E, Jurowicz M, Rakus D (Nov 2009). "Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence". Proteins. 77 (2): 262–7. doi:10.1002/prot.22506. PMID 19626708.
• Zhang Y, Liang JY, Huang S, Ke H, Lipscomb WN (Feb 1993). "Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase". Biochemistry. 32 (7): 1844–57. doi:10.1021/bi00058a019. PMID 8382525.
• Visinoni S, Khalid NF, Joannides CN, Shulkes A, Yim M, Whitehead J, Tiganis T, Lamont BJ, Favaloro JM, Proietto J, Andrikopoulos S, Fam BC (May 2012). "The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity". Diabetes. 61 (5): 1122–32. doi:10.2337/db11-1511. PMC 3331739. PMID 22517657.
• Liu X, Wang X, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ, Jin HC (Jan 2010). "Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis". Oncogene. 29 (3): 442–50. doi:10.1038/onc.2009.332. PMID 19881551.
• Kikawa Y, Inuzuka M, Jin BY, Kaji S, Koga J, Yamamoto Y, Fujisawa K, Hata I, Nakai A, Shigematsu Y, Mizunuma H, Taketo A, Mayumi M, Sudo M (Oct 1997). "Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency". American Journal of Human Genetics. 61 (4): 852–61. doi:10.1086/514875. PMC 1715983. PMID 9382095.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.