Endonuclease/Exonuclease/phosphatase family

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Endonuclease/Exonuclease/phosphatase family
Identifiers
SymbolExo_endo_phos
PfamPF03372
InterProIPR005135
PROSITEPDOC00598
SCOP1ako
SUPERFAMILY1ako
OPM superfamily148
OPM protein1zwx

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling [1].

Examples

Subfamilies

Human proteins containing this domain

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP;

Notes

  1. Dlaki M (2000). "Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–273. PMID 10838565.

References

  • [1]. Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Dlakic M; Trends Biochem Sci 2000;25:272-273. PMID 10838565
  • [2]. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; Nature 1995;374:381-386. PMID 7885481
  • [3]. DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. Lahm A, Suck D; J Mol Biol 1991;222:645-667. PMID 1748997

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