Delayed puberty classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]
Overview
Delayed puberty is almost always due to physiologic exaggeration of the prolongation of puberty timing; a condition called constitutional delay of growth and puberty (CDGP). Other forms of delayed puberty include hypergonadotropic hypogonadism, permanent hypogonadotropic hypogonadism, and functional hypogonadotropic hypogonadism.
Classification
- Delayed puberty may be classified according to etiology into 4 subtypes which includes:[1]
- Constitutional delay of growth and puberty (CDGP)
- Hypergonadotropic hypogonadism
- Permanent hypogonadotropic hypogonadism
- Functional hypogonadotropic hypogonadism
- The most common subtype of delayed puberty, constitutional delay of growth and puberty (CDGP), has no pathological etiology and is completely physiologic.
- Other subtypes of delayed puberty are classified upon the serum levels of sex hormones and also gonadotropins.
- The complete classification of delayed puberty is as follows:
Delayed puberty classification | |||||||||||||||||||||||||||||||||||||||||||||||||
LH, FSH, and GnRH plasma level | |||||||||||||||||||||||||||||||||||||||||||||||||
Normal | Abnormal | ||||||||||||||||||||||||||||||||||||||||||||||||
Constitutional delay of growth and puberty (CDGP) | LH and FSH increased GnRH increased | LH and FSH decreased GnRH decreased | LH and FSH decreased GnRH decreased (transient) | ||||||||||||||||||||||||||||||||||||||||||||||
Hypergonadotropic hypogonadism (primary hypogonadism) | Permanent hypogonadotropic hypogonadism (secondary hypogonadism) | Transient hypogonadotropic hypogonadism (functional hypogonadism) | |||||||||||||||||||||||||||||||||||||||||||||||
References
- ↑ Palmert, Mark R.; Dunkel, Leo (2012). "Delayed Puberty". New England Journal of Medicine. 366 (5): 443–453. doi:10.1056/NEJMcp1109290. ISSN 0028-4793.
- ↑ 2.0 2.1 CC BY-SA 3.0> "https://commons.wikimedia.org/wiki/File%3AFlow_diagram_showing_normal_hormonal_control_of_puberty.gif">via Wikimedia Commons