Bromo-DragonFLY

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Bromo-DragonFLY
Chemical name Bromo-benzodifuranyl-isopropylamine or
(1-(8-bromobenzo[1,2-b;4,5-b']difuran-
4-yl)-2-aminopropane
Chemical formula C13H12BrNO2
Molecular mass 294.14 g/mol
Melting point decomposes at 240 °C (hydrochloride)
CAS number -
SMILES N[C@H](C)CC1=C(OC=C2)C2=
C(Br)C3=C1C=CO3 (R-isomer)

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Overview

Bromo-DragonFLY, also known as ABDF, is a psychedelic hallucinogenic drug somewhat related to the phenethylamine family. Bromo-DragonFLY is considered an extremely potent hallucinogen, only slightly less potent than LSD with a normal dose in the region of 200μg to 800μg, and it has an extremely long duration of action. It is not illegal anywhere in the world at this time (except in Sweden, where it is classified as an narcotic) although it may be considered a controlled substance analogue under US and Australian drug laws. Bromo-DragonFLY has a stereocenter and R-(-)-bromo-DragonFLY is the more active stereoisomer.

Pharmacology

The hallucinogenic effect of bromo-DragonFLY is mediated by its agonist activity at the 5-HT2A serotonin receptor. Bromo-DragonFLY also has a high binding affinity for the 5-HT2B and 5-HT2C serotonin receptor. User reports of the effects of bromo-DragonFLY suggest that while the effects are very long lasting, they tend to be somewhat milder than those of traditional hallucinogens such as LSD, suggesting that while bromo-DragonFLY is a full agonist at the 5HT2A receptor, it may not be activating the intracellular signalling pathways following receptor binding as effectively as LSD.

History

Bromo-DragonFLY was first synthesized by Matthew A. Parker in the laboratory of David E. Nichols in 1998.

Deaths

Bromo-DragonFLY can sometimes be found on "blotters" (small bits of paper containing the substance) reminiscent of the most commonly found form of LSD, thus making it difficult to identify which substance it is carrying. Erowid reports two news stories, one in Sweden and one in Norway, about deaths possibly involved with bromo-dragonFLY. Erowid Bromo-Dragonfly vault

See also

References

  • 'A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor' by M. A. Parker, D. Marona-Lewicka, V. L. Lucaites, D. L. Nelson, and D. E. Nichols in J. Med. Chem. 41(26): 5148-5149 (1998) DOI: 10.1021/jm9803525
  • 'Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT2A/2C receptor agonists' by J. J. Chambers, D. M. Kurrasch-Orbaugh, M. A. Parker, and D. E. Nichols in J. Med. Chem. 44(6): 1003-1010 (2001) DOI: 10.1021/jm000491y

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