Boromycin

Boromycin

File:Boromycin.png
Identifiers
CAS Number	34524-20-4
PubChem CID	6436027
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C45H74BNO15
Molar mass	879.878 g/mol

WikiDoc Resources for Boromycin
Articles
Most recent articles on Boromycin Most cited articles on Boromycin Review articles on Boromycin Articles on Boromycin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Boromycin Images of Boromycin Photos of Boromycin Podcasts & MP3s on Boromycin Videos on Boromycin
Evidence Based Medicine
Cochrane Collaboration on Boromycin Bandolier on Boromycin TRIP on Boromycin
Clinical Trials
Ongoing Trials on Boromycin at Clinical Trials.gov Trial results on Boromycin Clinical Trials on Boromycin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Boromycin NICE Guidance on Boromycin NHS PRODIGY Guidance FDA on Boromycin CDC on Boromycin
Books
Books on Boromycin
News
Boromycin in the news Be alerted to news on Boromycin News trends on Boromycin
Commentary
Blogs on Boromycin
Definitions
Definitions of Boromycin
Patient Resources / Community
Patient resources on Boromycin Discussion groups on Boromycin Patient Handouts on Boromycin Directions to Hospitals Treating Boromycin Risk calculators and risk factors for Boromycin
Healthcare Provider Resources
Symptoms of Boromycin Causes & Risk Factors for Boromycin Diagnostic studies for Boromycin Treatment of Boromycin
Continuing Medical Education (CME)
CME Programs on Boromycin
International
Boromycin en Espanol Boromycin en Francais
Business
Boromycin in the Marketplace Patents on Boromycin
Experimental / Informatics
List of terms related to Boromycin

Boromycin is a bacteriocidal polyether-macrolide antibiotic. It was initially isolated from the Streptomyces strain Streptomyces antibioticus, and is notable for being the first natural product found to contain the element boron. It is effective against most Gram-positive bacteria, but is ineffective against Gram-negative bacteria. Boromycin kills bacteria by negatively affecting the cytoplasmic membrane, resulting in the loss of potassium ions from the cell.

Anti-HIV activity

Recent studies have suggested that boromycin has potent anti-HIV activity. It was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in vitro. The mechanism of action for the anti-HIV activity of boromycin is suggested to involve interfering with the later stage of HIV infection, and possibly the maturation step for the replication of HIV.

References

• Kohno J, Kawahata T, Otake T, Morimoto M, Mori H, Ueba N, Nishio M, Kinumaki A, Komatsubara S, Kawashima K. (1996). "Boromycin, an anti-HIV antibiotic". Biosci Biotechnol Biochem. 60 (6): 1036–7.CS1 maint: Multiple names: authors list (link)
• "On the Biosynthesis of Boromycin" (PDF). Journal of Organic Chemistry. 46: 2661–2665. 1981.

" ignored (help) 

• R. Hütter, W. Keller-Schien, F. Knüsel, V. Prelog , G. C. Rodgers jr., P. Suter, G. Vogel, W. Voser, H. Zähner (1967). "Stoffwechselprodukte von Mikroorganismen. 57. Mitteilung. Boromycin". Helv. Chim. Acta. 50: 1533–1539. doi:10.1002/hlca.19670500612.CS1 maint: Multiple names: authors list (link)
• J. D. Dunitz, D. M. Hawley, D. Miklo, D. N. J. White, Yu. Berlin, R. Marui, V. Prelog (1971). "Structure of boromycin". Helv. Chim. Acta. 54: 1709–1713. doi:10.1002/hlca.19710540624.CS1 maint: Multiple names: authors list (link)

Template:WH Template:WS