Beta-thalassemia surgery
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Surgical intervention is frequently required to guarantee optimum management of the accompanying morbidity in beta-thalassemia cases. The most prevalent types of surgical interventions associated with beta-thalassemia include splenectomy, cholecystectomy, leg ulcers, fractures, and extramedullary pseudotumor.
Surgery
Surgical intervention is frequently required to guarantee optimum management of the accompanying morbidity in beta-thalassemia cases. Before undergoing surgical intervention, there are a few things of a more general nature that need to be taken into mind:
- Anemia
- Cardiovascular disease
- Thromboembolic events
- The consequences of iron overload
The most prevalent types of surgical interventions associated with beta-thalassemia include:
- Splenectomy: In severe cases with significant splenomegaly, splenectomy may be considered. This would help improve anemia and reduce transfusion requirements.
- Cholecystectomy: Recurrent gallstone due to chronic hemolysis.
- Leg ulcers
- Fractures
- Extramedullary pseudotumor[1][2][3].
References
- ↑ Saad GS, Musallam KM, Taher AT (June 2011). "The surgeon and the patient with β-thalassaemia intermedia". Br J Surg. 98 (6): 751–60. doi:10.1002/bjs.7533. PMID 21480198.
- ↑ Ali S, Mumtaz S, Shakir HA, Khan M, Tahir HM, Mumtaz S, Mughal TA, Hassan A, Kazmi S, Sadia, Irfan M, Khan MA (December 2021). "Current status of beta-thalassemia and its treatment strategies". Mol Genet Genomic Med. 9 (12): e1788. doi:10.1002/mgg3.1788. PMC 8683628 Check
|pmc=value (help). PMID 34738740 Check|pmid=value (help). Vancouver style error: initials (help) - ↑ Khandros E, Kwiatkowski JL (June 2019). "Beta Thalassemia: Monitoring and New Treatment Approaches". Hematol Oncol Clin North Am. 33 (3): 339–353. doi:10.1016/j.hoc.2019.01.003. PMID 31030806.