Beta-thalassemia MRI
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Abdominopelvic MRI can suggest hepatosplenomegaly. MRI with T2 star sequence is a particular sequence of MRI that specifically assesses for iron overload states. MRI with T2 star of the heart or liver can help determine the degree of iron overload.
MRI Findings
- The role of MRI in beta-thalassemia work-up is limited. Abdominopelvic MRI can suggest hepatosplenomegaly.
- MRI with T2 star sequence: This is a particular sequence of MRI that specifically assesses for iron overload states. MRI with T2 star of the heart or liver can help determine the degree of iron overload.
- The T2 relaxation enhancement induced by interactions between high-molecular-weight iron complexes such as ferritin, hemosiderin, and deferoxamine with water molecules is the basis for the MRI evaluation of tissue iron overload. This enhancement can be seen when the tissue contains excessive iron.[1][2]
References
- ↑ Gossuin Y, Muller RN, Gillis P (November 2004). "Relaxation induced by ferritin: a better understanding for an improved MRI iron quantification". NMR Biomed. 17 (7): 427–32. doi:10.1002/nbm.903. PMID 15526352.
- ↑ Gossuin Y, Roch A, Muller RN, Gillis P, Lo Bue F (December 2002). "Anomalous nuclear magnetic relaxation of aqueous solutions of ferritin: an unprecedented first-order mechanism". Magn Reson Med. 48 (6): 959–64. doi:10.1002/mrm.10316. PMID 12465104.