Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10gene.[1][2][3]
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus preventing caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.[3]
References
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Pan G, O'Rourke K, Dixit VM (1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex". J. Biol. Chem. 273 (10): 5841–5. doi:10.1074/jbc.273.10.5841. PMID9488720.
Ke N, Godzik A, Reed JC (2001). "Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak". J. Biol. Chem. 276 (16): 12481–4. doi:10.1074/jbc.C000871200. PMID11278245.
Naumann U, Weit S, Wischhusen J, Weller M (2001). "Diva/Boo is a negative regulator of cell death in human glioma cells". FEBS Lett. 505 (1): 23–6. doi:10.1016/S0014-5793(01)02768-5. PMID11557035.
Aouacheria A, Arnaud E, Venet S, et al. (2001). "Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis". Oncogene. 20 (41): 5846–55. doi:10.1038/sj.onc.1204740. PMID11593390.
Zhang H, Holzgreve W, De Geyter C (2002). "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway". Hum. Mol. Genet. 10 (21): 2329–39. doi:10.1093/hmg/10.21.2329. PMID11689480.
Li Z, Takeuchi S, Ohara N, Maruo T (2003). "Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma". Int. J. Clin. Oncol. 8 (2): 83–9. doi:10.1007/s101470300015. PMID12720100.
Kang Y, Lee DC, Han J, et al. (2007). "NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling". Biochem. Biophys. Res. Commun. 359 (1): 76–82. doi:10.1016/j.bbrc.2007.05.090. PMID17532299.
Guillemin Y, Lalle P, Gillet G, et al. (2009). "Oocytes and early embryos selectively express the survival factor BCL2L10". J. Mol. Med. 87 (9): 923–40. doi:10.1007/s00109-009-0495-7. PMID19551325.
