Aprindine

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Aprindine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C01BB04 (WHO) ;
Identifiers
	IUPAC name {3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine;
CAS Number	37640-71-4;
PubChem CID	2218;
DrugBank	DB01429 ;
ChemSpider	2132 ;
UNII	5Y48085P9Q;
KEGG	D02969 ;
ChEMBL	ChEMBL1213033 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C22H30N2
Molar mass	322.487 g/mol
3D model (JSmol)	Interactive image;
	SMILES c1cccc3c1CC(N(c2ccccc2)CCCN(CC)CC)C3;
	InChI InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3 ; Key:NZLBHDRPUJLHCE-UHFFFAOYSA-N ;
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Aprindine is a Class 1b antiarrhythmic agent.^[1]

In one study, it delayed atrial fibrillation more than digoxin did.^[2]

It has shown effectiveness when given orally.^[3]

↑ Sato R, Hisatome I, Tanaka Y; et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
↑ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation" (^{[dead link]}). Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.
↑ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J. 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.