Alamethicin

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Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride. It contains the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib), which strongly induces helical peptide structures. The peptide sequence is:

Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl

(Ac = acetyl, Phl = phenylalaninol)

  • Molecular Formula: C92H150N22O25
  • CAS number: 27061-78-5
  • Appearance: Off white solid
  • UV spectrum maxima: 265, 257
  • Melting point: 255°C-270°C
  • Solubility information: DMSO, Methanol, Ethanol. Not soluble in water

In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules.

data copied from Fermentek Alamethicin product page




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