Acute pancreatitis secondary prevention

Jump to: navigation, search

Acute pancreatitis Microchapters


American College of Gastroenterology Guidelines

Patient Information


Historical Perspective




Differentiating Acute Pancreatitis from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic criteria

History and Symptoms

Physical Examination

Laboratory Findings

Abdominal X Ray




Other Imaging Findings

Other Diagnostic Studies


Approach to Therapy

Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Acute pancreatitis secondary prevention On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Acute pancreatitis secondary prevention

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Acute pancreatitis secondary prevention

CDC on Acute pancreatitis secondary prevention

Acute pancreatitis secondary prevention in the news

Blogs on Acute pancreatitis secondary prevention

Directions to Hospitals Treating Acute pancreatitis

Risk calculators and risk factors for Acute pancreatitis secondary prevention

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]


The secondary prevention of acute pancreatitis primarily focuses on prevention of recurrence. The secondary prevention of acute pancreatitis varies according to the underlying etiology of the primary event. Cholecystectomy, alcohol abstinence, withdrawal of aggravating medications, weight control, and control of hyperlipidemia are among the most common methods of preventing recurrence of acute pancreatitis.[1]

Secondary Prevention

The secondary prevention of acute pancreatitis varies according to the underlying etiology of the primary event.


A delay of cholecystectomy for more than a few weeks after acute pancreatitis puts the patient at a high risk for relapse. There is a correlation between delay of cholecystectomy and rate of recurrence. For patients in which cholecystectomy cannot be safely performed. Endoscopic biliary sphincterotomy may prevent recurrence of pancreatitis.[2][1]

Alcohol Abstinence

Patients who developed acute pancreatitis secondary to alcohol abuse are at high risk of recurrent pancreatitis or even chronic pancreatitis. ~50% of patients with alcoholic pancreatitis suffer from recurrence if they continue abusing alcohol. The risk is significantly reduced after abstaining from alcohol. A focused approach directed at alcohol and smoking cessation should be taken with the patient.[3][4][1]

Withdrawal of Medication

Identifying the offending medication is a challenging task and is often not achieved. In the absence of any aggrevating conditions, a trial of changing drug regimens or cessation of an implicated drug may be reasonable after discussion with the prescribing physician.[5][1]

Control of Hyperlipidemia

Control of hypertriglyceridemia is effective in preventing recurrence of pancreatitis. Repeated measurements of serum triglycerides after discharge may be beneficial.[6][7][1]


  1. 1.0 1.1 1.2 1.3 1.4 Forsmark CE, Vege SS, Wilcox M (November 17,2016). "Acute Pancreatitis". The New England Journal of Medicine: 1972–1981. doi:10.1056/NEJMra1505202. Retrieved November 25,2016. Check date values in: |access-date=, |date= (help)
  2. van Baal MC, Besselink MG, Bakker OJ, van Santvoort HC, Schaapherder AF, Nieuwenhuijs VB; et al. (2012). "Timing of cholecystectomy after mild biliary pancreatitis: a systematic review". Ann Surg. 255 (5): 860–6. doi:10.1097/SLA.0b013e3182507646. PMID 22470079. Review in: Evid Based Med. 2013 Apr;18(2):e11
  3. Sand J, Lankisch PG, Nordback I (2007). "Alcohol consumption in patients with acute or chronic pancreatitis". Pancreatology. 7 (2–3): 147–56. doi:10.1159/000104251. PMID 17592227.
  4. Pelli H, Lappalainen-Lehto R, Piironen A, Sand J, Nordback I (2008). "Risk factors for recurrent acute alcohol-associated pancreatitis: a prospective analysis". Scand J Gastroenterol. 43 (5): 614–21. doi:10.1080/00365520701843027. PMID 18415757.
  5. Kaurich T (2008). "Drug-induced acute pancreatitis". Proc (Bayl Univ Med Cent). 21 (1): 77–81. PMC 2190558. PMID 18209761.
  6. Yadav D, Pitchumoni CS (2003). "Issues in hyperlipidemic pancreatitis". J Clin Gastroenterol. 36 (1): 54–62. PMID 12488710.
  7. Valdivielso P, Ramírez-Bueno A, Ewald N (2014). "Current knowledge of hypertriglyceridemic pancreatitis". Eur J Intern Med. 25 (8): 689–94. doi:10.1016/j.ejim.2014.08.008. PMID 25269432.