|Locus||Chr. 1 q43|
5-Methyltetrahydrofolate-homocysteine methyltransferase or (MTR) is an enzyme responsible for the production of methionine from homocysteine. MTR forms part of the S-adenosyl methionine cycle and is also called methionine synthase.
The enzyme works in two steps in a ping-pong reaction. First, methylcobalamin is formed by a methyl group transfer from N5-mTHF with formation of MeB12 and tetrahydrofolate (THF). In the second step, MeB12 transfers this methyl group to (homocysteine), regenerating the cofactor cobalamin and releasing the product methionine
- ENZYME: EC 188.8.131.52
- 5-Methyltetrahydrofolate-Homocysteine+S-Methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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