Waldenström's macroglobulinemia risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]

Overview

Common risk factors in the development of Waldenström's macroglobulinemia are Monoclonal gammopathy of undetermined significance, old age, white ethnicity, hereditary, hepatitis C, and immune disorders.

Risk factors

Following are the common risk factors associated with Waldenström's macroglobulinemia:

Monoclonal gammopathy of undetermined significance

Pre-existing Monoclonal gammopathy of undetermined significance is the most common risk factor for the development of Waldenström's macroglobulinemia.

Age

The risk of Waldenström's macroglobulinemia increases after 50 years of age.

Race

Waldenström's macroglobulinemia is more common among whites.

Sex

Men are more likely than women to develop Waldenström's macroglobulinemia.

Heredity

Patients with Waldenström's macroglobulinemia has a close relative with the disease or with a related B-cell disease, such as MGUS or certain types of lymphoma or leukemia.

Hepatitis C

Patients with chronic hepatitis C infection are more likely to develop Waldenström's macroglobulinemia than general population.

Immune Diseases

Autoimmune diseases, such as Sjögren (Sjogren) syndrome, increase the risk of developing Waldenström's macroglobulinemia.