Uveitis pathophysiology: Difference between revisions
Tarek Nafee (talk | contribs) |
Tarek Nafee (talk | contribs) |
||
| Line 11: | Line 11: | ||
==Associated Conditions== | ==Associated Conditions== | ||
The following conditions are associated with uveitis:<ref name="pmid8619771">{{cite journal| author=Rodriguez A, Calonge M, Pedroza-Seres M, Akova YA, Messmer EM, D'Amico DJ et al.| title=Referral patterns of uveitis in a tertiary eye care center. | journal=Arch Ophthalmol | year= 1996 | volume= 114 | issue= 5 | pages= 593-9 | pmid=8619771 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8619771 }} </ref><ref name=eyewikiuveitis>American Academy of Ophthalmology EyeWiki(2015)http://eyewiki.aao.org/Category:Uveitis</ref><ref name="pmid20943722">{{cite journal| author=Guly CM, Forrester JV| title=Investigation and management of uveitis. | journal=BMJ | year= 2010 | volume= 341 | issue= | pages= c4976 | pmid=20943722 | doi=10.1136/bmj.c4976 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20943722 }} </ref> | The following conditions are associated with uveitis:<ref name="pmid8619771">{{cite journal| author=Rodriguez A, Calonge M, Pedroza-Seres M, Akova YA, Messmer EM, D'Amico DJ et al.| title=Referral patterns of uveitis in a tertiary eye care center. | journal=Arch Ophthalmol | year= 1996 | volume= 114 | issue= 5 | pages= 593-9 | pmid=8619771 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8619771 }} </ref><ref name=eyewikiuveitis>American Academy of Ophthalmology EyeWiki(2015)http://eyewiki.aao.org/Category:Uveitis</ref><ref name="pmid20943722">{{cite journal| author=Guly CM, Forrester JV| title=Investigation and management of uveitis. | journal=BMJ | year= 2010 | volume= 341 | issue= | pages= c4976 | pmid=20943722 | doi=10.1136/bmj.c4976 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20943722 }} </ref> | ||
{{MultiCol}} | |||
*[[Seronegative spondyloarthropathy]] | *[[Seronegative spondyloarthropathy]] | ||
*[[Sarcoidosis]] | *[[Sarcoidosis]] | ||
| Line 22: | Line 23: | ||
*[[Fuch's heterochromic iridocyclitis]] | *[[Fuch's heterochromic iridocyclitis]] | ||
*[[Lymphoma]] | *[[Lymphoma]] | ||
{{ColBreak}} | |||
*[[Lyme Disease]] | *[[Lyme Disease]] | ||
*[[Acquired immunodeficiency syndrome]] (AIDS) | *[[Acquired immunodeficiency syndrome]] (AIDS) | ||
| Line 33: | Line 35: | ||
*[[Rubella]] | *[[Rubella]] | ||
*[[Cat scratch disease]] (''[[Bartonella|Bartonella spp.]]'') | *[[Cat scratch disease]] (''[[Bartonella|Bartonella spp.]]'') | ||
{{EndMultiCol}} | |||
==Gross Pathology== | ==Gross Pathology== | ||
Revision as of 16:25, 27 July 2016
|
Uveitis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Uveitis pathophysiology On the Web |
|
American Roentgen Ray Society Images of Uveitis pathophysiology |
|
Risk calculators and risk factors for Uveitis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]
Overview
Pathogenesis
The exact pathogenesis of uveitis is not fully understood. It is thought that uveitis is mediated by either genetic factors, cross immunity to infectious agents, or cross immunity to self-antigens due to underlying autoimmune diseases. Up to 35% of cases of uveitis are idiopathic.[1] Uveitis in the setting of underlying infectious diseases is hypothesized to be secondary to a T-cell mediated hypersensitivity reaction resulting in immunoactivating cytokine production by proliferating Tн17 and Tн1 cells.[2][3] A similar mechanism is hypothesized for autoimmune etiologies of uveitis with the exception of an unknown source of the triggering antigen.[4][5][6][7]
Genetics
Associated Conditions
The following conditions are associated with uveitis:[1][8][9]
Gross Pathology
Anterior Uveitis
Intermediate Uveitis
Posterior Uveitis
Microscopic Pathology
Anterior Uveitis
Intermediate Uveitis
Posterior Uveitis
References
- ↑ 1.0 1.1 Rodriguez A, Calonge M, Pedroza-Seres M, Akova YA, Messmer EM, D'Amico DJ; et al. (1996). "Referral patterns of uveitis in a tertiary eye care center". Arch Ophthalmol. 114 (5): 593–9. PMID 8619771.
- ↑ Przeździecka-Dołyk J, Węgrzyn A, Turno-Kręcicka A, Misiuk-Hojło M (2016). "Immunopathogenic Background of Pars Planitis". Arch Immunol Ther Exp (Warsz). 64 (2): 127–37. doi:10.1007/s00005-015-0361-y. PMC 4805694. PMID 26438050.
- ↑ Urban B, Bakunowicz-Łazarczyk A, Michalczuk M (2014). "Immune recovery uveitis: pathogenesis, clinical symptoms, and treatment". Mediators Inflamm. 2014: 971417. doi:10.1155/2014/971417. PMC 4096001. PMID 25089078.
- ↑ Sun D, Liang D, Kaplan HJ, Shao H (2015). "The role of Th17-associated cytokines in the pathogenesis of experimental autoimmune uveitis (EAU)". Cytokine. 74 (1): 76–80. doi:10.1016/j.cyto.2014.12.017. PMC 4457592. PMID 25742774.
- ↑ Bi HS, Liu ZF, Cui Y (2015). "Pathogenesis of innate immunity and adaptive immunity in the mouse model of experimental autoimmune uveitis". J Chin Med Assoc. 78 (5): 276–82. doi:10.1016/j.jcma.2015.01.002. PMID 25769932.
- ↑ Horai R, Caspi RR (2011). "Cytokines in autoimmune uveitis". J Interferon Cytokine Res. 31 (10): 733–44. doi:10.1089/jir.2011.0042. PMC 3189550. PMID 21787221.
- ↑ Ke Y, Liu K, Huang GQ, Cui Y, Kaplan HJ, Shao H; et al. (2009). "Anti-inflammatory role of IL-17 in experimental autoimmune uveitis". J Immunol. 182 (5): 3183–90. doi:10.4049/jimmunol.0802487. PMC 3275433. PMID 19234216.
- ↑ American Academy of Ophthalmology EyeWiki(2015)http://eyewiki.aao.org/Category:Uveitis
- ↑ Guly CM, Forrester JV (2010). "Investigation and management of uveitis". BMJ. 341: c4976. doi:10.1136/bmj.c4976. PMID 20943722.