Tropheryma whipplei: Difference between revisions
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'''''Tropheryma whipplei''''' is a [[Bacteria|bacterium]] and the causative organism of [[Whipple's disease]].<ref name=La_Scola_2001>{{{cite journal |author=La Scola B, Fenollar F, Fournier P, Altwegg M, Mallet M, Raoult D |title=Description of ''Tropheryma whipplei'' gen. nov., sp. nov., the Whipple's disease bacillus |journal=Int J Syst Evol Microbiol |volume=51 |issue=Pt 4 |pages=1471-9 |year=2001 |url=http://ijs.sgmjournals.org/cgi/content/abstract/51/4/1471 |pmid=11491348}}</ref> While ''T. whipplei'' is categorized with the [[Gram-positive]] [[Actinobacteria]], the organism is commonly found to be [[Gram-negative]] or Gram-indeterminate when stained in the laboratory.<ref name=La_Scola_2001 /> [[George Hoyt Whipple|Whipple]] himself probably observed the organisms as rod-shaped structures with silver stain in his original case,<ref>{{cite journal | author=Whipple GH. | title=A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and msenteric lymphatic tissues | journal=Johns Hopkins Hosp Bull | year=1907 | volume=18 | pages=382–91 }}</ref> but no name was given to the organism until 1991 when the name ''Tropheryma whippelii'' was proposed after sections of the bacterial [[genome]] were sequenced.<ref>{{cite journal |author=Relman D, Schmidt T, MacDermott R, Falkow S |title=Identification of the uncultured bacillus of Whipple's disease |journal=N Engl J Med |volume=327 |issue=5 |pages=293-301 |year=1992 |pmid=1377787}}</ref> The name was changed to ''Tropheryma whipplei'' in 2001 (correcting the spelling of Whipple's name) after deposition in bacterial collections.<ref name=La_Scola_2001 /> | '''''Tropheryma whipplei''''' is a [[Bacteria|bacterium]] and the causative organism of [[Whipple's disease]].<ref name=La_Scola_2001>{{{cite journal |author=La Scola B, Fenollar F, Fournier P, Altwegg M, Mallet M, Raoult D |title=Description of ''Tropheryma whipplei'' gen. nov., sp. nov., the Whipple's disease bacillus |journal=Int J Syst Evol Microbiol |volume=51 |issue=Pt 4 |pages=1471-9 |year=2001 |url=http://ijs.sgmjournals.org/cgi/content/abstract/51/4/1471 |pmid=11491348}}</ref> While ''T. whipplei'' is categorized with the [[Gram-positive]] [[Actinobacteria]], the organism is commonly found to be [[Gram-negative]] or Gram-indeterminate when stained in the laboratory.<ref name=La_Scola_2001 /> [[George Hoyt Whipple|Whipple]] himself probably observed the organisms as rod-shaped structures with silver stain in his original case,<ref>{{cite journal | author=Whipple GH. | title=A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and msenteric lymphatic tissues | journal=Johns Hopkins Hosp Bull | year=1907 | volume=18 | pages=382–91 }}</ref> but no name was given to the organism until 1991 when the name ''Tropheryma whippelii'' was proposed after sections of the bacterial [[genome]] were sequenced.<ref>{{cite journal |author=Relman D, Schmidt T, MacDermott R, Falkow S |title=Identification of the uncultured bacillus of Whipple's disease |journal=N Engl J Med |volume=327 |issue=5 |pages=293-301 |year=1992 |pmid=1377787}}</ref> The name was changed to ''Tropheryma whipplei'' in 2001 (correcting the spelling of Whipple's name) after deposition in bacterial collections.<ref name=La_Scola_2001 /> | ||
Revision as of 15:59, 23 October 2017
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| Tropheryma whipplei La Scola et al 2001 |
Tropheryma whipplei is a bacterium and the causative organism of Whipple's disease.[1] While T. whipplei is categorized with the Gram-positive Actinobacteria, the organism is commonly found to be Gram-negative or Gram-indeterminate when stained in the laboratory.[1] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case,[2] but no name was given to the organism until 1991 when the name Tropheryma whippelii was proposed after sections of the bacterial genome were sequenced.[3] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) after deposition in bacterial collections.[1]
Pathogenesis
References
- ↑ 1.0 1.1 1.2 {La Scola B, Fenollar F, Fournier P, Altwegg M, Mallet M, Raoult D (2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int J Syst Evol Microbiol. 51 (Pt 4): 1471–9. PMID 11491348.
- ↑ Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and msenteric lymphatic tissues". Johns Hopkins Hosp Bull. 18: 382&ndash, 91.
- ↑ Relman D, Schmidt T, MacDermott R, Falkow S (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med. 327 (5): 293–301. PMID 1377787.