Transposition of the great vessels causes: Difference between revisions

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(New page: {{Template:Transposition of the great vessels}} {{CMG}} ==Causes== The cause of most congenital heart defects is unknown. Factors in the mother that may increase the risk of this conditi...)
 
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{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com]; {{CZ}}; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu];[[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu]
==Overview==
The causes for transposition of the great arteries is unknown and is presumed to be multifactorial. The embryology likely involves abnormal persistence of the subaortic conus with resorption or underdevelopment of the subpulmonary conus (infundibulum). This abnormality aligns the aorta anterior and superior with the right ventricle during development.
==Causes==
==Causes==
The cause of most congenital heart defects is unknown.


Factors in the mother that may increase the risk of this condition include:
*The etiology for transposition of the great arteries is unknown and is presumed to be multifactorial.<ref name="Praagh2010">{{cite journal|last1=Praagh|first1=Richard Van|title=Normally and Abnormally Related Great Arteries|journal=World Journal for Pediatric and Congenital Heart Surgery|volume=1|issue=3|year=2010|pages=364–385|issn=2150-1351|doi=10.1177/2150135110380239}}</ref>
*Age over 40
*The embryology likely involves abnormal persistence of the subaortic conus with resorption or underdevelopment of the infundibulum. This abnormality aligns the [[aorta]] anterior and superior with the [[right ventricle]] during development.
*Alcoholism
*Generally, TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of chromosome 22q11.
*Diabetes
*Prenatal nutrition
*Rubella or other viral illness during pregnancy
 
Transposition of the great vessels is a cyanotic heart defect. This means there is decreased oxygen in the blood that is pumped from the heart to the rest of the body. Low blood oxygen leads to [[cyanosis]] (a bluish-purple color to the skin) and shortness of breath.
 
In normal hearts, blood that returns from the body goes through the right side of the heart and pulmonary artery to the lungs to get oxygen. The blood then comes back to the left side of the heart and travels out the aorta to the body.In transposition of the great vessels, the blood goes to the lungs, picks up oxygen, and then goes right back to the lungs without ever going to the body. Blood from the body returns to the heart and goes back to the body without ever picking up oxygen in the lungs. Symptoms appear at birth or very soon afterward. How bad the symptoms are depends on the type and size of heart defects (such as [[atrial septal defect]] or [[patent ductus arteriosus]]) and how much oxygen moves through the body's general blood flow.  
 
The condition is the second most common cyanotic heart defect. More details about the genetics causation can be found in the microchapter below:
====[[Transposition of the great vessels causes genetics|Genetics]]====


==References==
==References==
{{reflist|2}}
{{reflist|2}}


[[fr:Transposition des gros vaisseaux]]
{{WH}}
[[nl:Transpositie van de grote vaten]]
{{WS}}
[[zh:大血管轉位]]


[[Category:DiseaseState]]
[[Category:Disease]]
[[Category:Cardiology]]
[[Category:Cardiology]]
[[Category:Congenital heart disease]]
[[Category:Congenital heart disease]]
{{WH}}
{{WS}}

Latest revision as of 17:01, 25 February 2020

Transposition of the great vessels Microchapters

Home

Patient Information

Overview

Historical perspective

Classification

Dextro-transposition of the great arteries
L-transposition of the great arteries

Pathophysiology

Causes

Differentiating Transposition of the great vessels from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

MRI

CT

Echocardiography

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Palliative care
Corrective surgery
Post-operative care
Follow up

Prevention

Reproduction

Case Studies

Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4];Kristin Feeney, B.S. [5]

Overview

The causes for transposition of the great arteries is unknown and is presumed to be multifactorial. The embryology likely involves abnormal persistence of the subaortic conus with resorption or underdevelopment of the subpulmonary conus (infundibulum). This abnormality aligns the aorta anterior and superior with the right ventricle during development.

Causes

  • The etiology for transposition of the great arteries is unknown and is presumed to be multifactorial.[1]
  • The embryology likely involves abnormal persistence of the subaortic conus with resorption or underdevelopment of the infundibulum. This abnormality aligns the aorta anterior and superior with the right ventricle during development.
  • Generally, TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of chromosome 22q11.

References

  1. Praagh, Richard Van (2010). "Normally and Abnormally Related Great Arteries". World Journal for Pediatric and Congenital Heart Surgery. 1 (3): 364–385. doi:10.1177/2150135110380239. ISSN 2150-1351.

Template:WH Template:WS