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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Retinoblastoma-binding protein 8''' is a [[protein]] that in humans is encoded by the ''RBBP8'' [[gene]].<ref name="pmid9721205">{{cite journal | vauthors = Fusco C, Reymond A, Zervos AS | title = Molecular cloning and characterization of a novel retinoblastoma-binding protein | journal = Genomics | volume = 51 | issue = 3 | pages = 351–8 | date = October 1998 | pmid = 9721205 | pmc =  | doi = 10.1006/geno.1998.5368 }}</ref><ref name="pmid17965729">{{cite journal | vauthors = Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP | title = Human CtIP promotes DNA end resection | journal = Nature | volume = 450 | issue = 7169 | pages = 509–14 | date = November 2007 | pmid = 17965729 | pmc = 2409435 | doi = 10.1038/nature06337 }}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Retinoblastoma binding protein 8
| HGNCid = 9891
| Symbol = RBBP8
| AltSymbols =; CTIP; RIM
| OMIM = 604124
| ECnumber = 
| Homologene = 28546
| MGIid = 2442995
| GeneAtlas_image1 = PBB_GE_RBBP8_203344_s_at_tn.png
| Function =  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5932
    | Hs_Ensembl = ENSG00000101773
    | Hs_RefseqProtein = NP_002885
    | Hs_RefseqmRNA = NM_002894
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 18767293
    | Hs_GenLoc_end = 18860443
    | Hs_Uniprot = Q99708
    | Mm_EntrezGene = 225182
    | Mm_Ensembl = ENSMUSG00000041238
    | Mm_RefseqmRNA = XM_484703
    | Mm_RefseqProtein = XP_484703
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 11776812
    | Mm_GenLoc_end = 11886351
    | Mm_Uniprot = 
  }}
}}
'''Retinoblastoma binding protein 8''', also known as '''RBBP8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RBBP8 retinoblastoma binding protein 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5932| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: RBBP8 retinoblastoma binding protein 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5932| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
==Interactions==
| summary_text = The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: RBBP8 retinoblastoma binding protein 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5932| accessdate = }}</ref>
RBBP8 has been shown to [[Protein-protein interaction|interact]] with:
}}
{{div col|colwidth=20em}}
* [[Ataxia telangiectasia mutated|ATM]],<ref name = pmid10910365>{{cite journal | vauthors = Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH | title = Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response | journal = Nature | volume = 406 | issue = 6792 | pages = 210–5 | date = July 2000 | pmid = 10910365 | doi = 10.1038/35018134 }}</ref><ref name = pmid10608806>{{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members | journal = J. Biol. Chem. | volume = 274 | issue = 53 | pages = 37538–43 | date = Dec 1999 | pmid = 10608806 | doi =  10.1074/jbc.274.53.37538}}</ref>
* [[BRCA1]],<ref name = pmid10910365/><ref name = pmid10196224/><ref name = pmid14578343>{{cite journal | vauthors = Rodriguez M, Yu X, Chen J, Songyang Z | title = Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52914–8 | date = Dec 2003 | pmid = 14578343 | doi = 10.1074/jbc.C300407200 }}</ref><ref name = pmid9811458>{{cite journal | vauthors = Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH, Bartel PL | title = Characterization of a carboxy-terminal BRCA1 interacting protein | journal = Oncogene | volume = 17 | issue = 18 | pages = 2279–85 | date = November 1998 | pmid = 9811458 | doi = 10.1038/sj.onc.1202150 }}</ref><ref name = pmid11689934>{{cite journal | vauthors = Wu-Baer F, Baer R | title = Effect of DNA damage on a BRCA1 complex | journal = Nature | volume = 414 | issue = 6859 | pages = 36 | date = November 2001 | pmid = 11689934 | doi = 10.1038/35102118 }}</ref><ref name = pmid9738006>{{cite journal | vauthors = Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R | title = The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression | journal = J. Biol. Chem. | volume = 273 | issue = 39 | pages = 25388–92 | date = September 1998 | pmid = 9738006 | doi =  10.1074/jbc.273.39.25388}}</ref><ref name = pmid10764811>{{cite journal | vauthors = Yu X, Baer R | title = Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor | journal = J. Biol. Chem. | volume = 275 | issue = 24 | pages = 18541–9 | date = June 2000 | pmid = 10764811 | doi = 10.1074/jbc.M909494199 }}</ref>
* [[CTBP1]],<ref name = pmid10196224>{{cite journal | vauthors = Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH | title = Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11334–8 | date = April 1999 | pmid = 10196224 | doi =  10.1074/jbc.274.16.11334}}</ref><ref name = pmid9535825>{{cite journal | vauthors = Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G | title = Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 8549–52 | date = April 1998 | pmid = 9535825 | doi =  10.1074/jbc.273.15.8549}}</ref>
* [[LMO4]],<ref name = pmid11751867>{{cite journal | vauthors = Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE | title = The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 7849–56 | date = March 2002 | pmid = 11751867 | doi = 10.1074/jbc.M110603200 }}</ref><ref name = pmid12925972>{{cite journal | vauthors = Sutherland KD, Visvader JE, Choong DY, Sum EY, Lindeman GJ, Campbell IG | title = Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas | journal = Int. J. Cancer | volume = 107 | issue = 1 | pages = 155–8 | date = October 2003 | pmid = 12925972 | doi = 10.1002/ijc.11343 }}</ref>
* [[Retinoblastoma protein|RB1]],<ref name = pmid9721205/><ref name = pmid10779361>{{cite journal | vauthors = Dick FA, Sailhamer E, Dyson NJ | title = Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3715–27 | date = May 2000 | pmid = 10779361 | pmc = 85672 | doi =  10.1128/mcb.20.10.3715-3727.2000}}</ref>
* [[Retinoblastoma-like protein 1|RBL1]],<ref name = pmid9721205/><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
* [[Retinoblastoma-like protein 2|RBL2]],<ref name = pmid9721205 />{<ref name = pmid10449734>{{cite journal | vauthors = Meloni AR, Smith EJ, Nevins JR | title = A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 17 | pages = 9574–9 | date = August 1999 | pmid = 10449734 | pmc = 22250 | doi =  10.1073/pnas.96.17.9574}}</ref>  and
* [[SIAH1]]<ref name = pmid14654780>{{cite journal | vauthors = Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H | title = SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway | journal = Oncogene | volume = 22 | issue = 55 | pages = 8845–51 | date = Dec 2003 | pmid = 14654780 | doi = 10.1038/sj.onc.1206994 }}</ref>
{{Div col end}}


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Deng CX, Brodie SG | title = Roles of BRCA1 and its interacting proteins | journal = BioEssays | volume = 22 | issue = 8 | pages = 728–37 | year = 2000 | pmid = 10918303 | doi = 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B }}
| citations =
*{{cite journal | vauthors = Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K | title = The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression | journal = Gene | volume = 146 | issue = 2 | pages = 199–207 | year = 1994 | pmid = 8076819 | doi = 10.1016/0378-1119(94)90293-3 }}
*{{cite journal | author=Deng CX, Brodie SG |title=Roles of BRCA1 and its interacting proteins. |journal=Bioessays |volume=22 |issue= 8 |pages= 728-37 |year= 2000 |pmid= 10918303 |doi= 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B }}
*{{cite journal | vauthors = Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G | title = Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 8549–52 | year = 1998 | pmid = 9535825 | doi = 10.1074/jbc.273.15.8549 }}
*{{cite journal | author=Matoba R, Okubo K, Hori N, ''et al.'' |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199-207 |year= 1994 |pmid= 8076819 |doi= }}
*{{cite journal | vauthors = Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R | title = The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression | journal = J. Biol. Chem. | volume = 273 | issue = 39 | pages = 25388–92 | year = 1998 | pmid = 9738006 | doi = 10.1074/jbc.273.39.25388 }}
*{{cite journal | author=Schaeper U, Subramanian T, Lim L, ''et al.'' |title=Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8549-52 |year= 1998 |pmid= 9535825 |doi= }}
*{{cite journal | vauthors = Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH, Bartel PL | title = Characterization of a carboxy-terminal BRCA1 interacting protein | journal = Oncogene | volume = 17 | issue = 18 | pages = 2279–85 | year = 1998 | pmid = 9811458 | doi = 10.1038/sj.onc.1202150 }}
*{{cite journal | author=Fusco C, Reymond A, Zervos AS |title=Molecular cloning and characterization of a novel retinoblastoma-binding protein. |journal=Genomics |volume=51 |issue= 3 |pages= 351-8 |year= 1998 |pmid= 9721205 |doi= 10.1006/geno.1998.5368 }}
*{{cite journal | vauthors = Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH | title = Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11334–8 | year = 1999 | pmid = 10196224 | doi = 10.1074/jbc.274.16.11334 }}
*{{cite journal | author=Yu X, Wu LC, Bowcock AM, ''et al.'' |title=The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. |journal=J. Biol. Chem. |volume=273 |issue= 39 |pages= 25388-92 |year= 1998 |pmid= 9738006 |doi= }}
*{{cite journal | vauthors = Meloni AR, Smith EJ, Nevins JR | title = A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 17 | pages = 9574–9 | year = 1999 | pmid = 10449734 | pmc = 22250 | doi = 10.1073/pnas.96.17.9574 }}
*{{cite journal | author=Wong AK, Ormonde PA, Pero R, ''et al.'' |title=Characterization of a carboxy-terminal BRCA1 interacting protein. |journal=Oncogene |volume=17 |issue= 18 |pages= 2279-85 |year= 1998 |pmid= 9811458 |doi= 10.1038/sj.onc.1202150 }}
*{{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members | journal = J. Biol. Chem. | volume = 274 | issue = 53 | pages = 37538–43 | year = 2000 | pmid = 10608806 | doi = 10.1074/jbc.274.53.37538 }}
*{{cite journal | author=Li S, Chen PL, Subramanian T, ''et al.'' |title=Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11334-8 |year= 1999 |pmid= 10196224 |doi= }}
*{{cite journal | vauthors = Yu X, Baer R | title = Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor | journal = J. Biol. Chem. | volume = 275 | issue = 24 | pages = 18541–9 | year = 2000 | pmid = 10764811 | doi = 10.1074/jbc.M909494199 }}
*{{cite journal | author=Meloni AR, Smith EJ, Nevins JR |title=A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9574-9 |year= 1999 |pmid= 10449734 |doi= }}
*{{cite journal | vauthors = Dick FA, Sailhamer E, Dyson NJ | title = Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3715–27 | year = 2000 | pmid = 10779361 | pmc = 85672 | doi = 10.1128/MCB.20.10.3715-3727.2000 }}
*{{cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538-43 |year= 2000 |pmid= 10608806 |doi= }}
*{{cite journal | vauthors = Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C | title = Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb | journal = FASEB J. | volume = 14 | issue = 7 | pages = 904–12 | year = 2000 | pmid = 10783144 | doi =  }}
*{{cite journal | author=Yu X, Baer R |title=Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18541-9 |year= 2000 |pmid= 10764811 |doi= 10.1074/jbc.M909494199 }}
*{{cite journal | vauthors = Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH | title = Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response | journal = Nature | volume = 406 | issue = 6792 | pages = 210–5 | year = 2000 | pmid = 10910365 | doi = 10.1038/35018134 }}
*{{cite journal | author=Dick FA, Sailhamer E, Dyson NJ |title=Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3715-27 |year= 2000 |pmid= 10779361 |doi= }}
*{{cite journal | vauthors = Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH | title = Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1 | journal = Mol. Cell | volume = 6 | issue = 4 | pages = 757–68 | year = 2000 | pmid = 11090615 | doi = 10.1016/S1097-2765(00)00075-7 }}
*{{cite journal | author=Fanciulli M, Bruno T, Di Padova M, ''et al.'' |title=Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. |journal=FASEB J. |volume=14 |issue= 7 |pages= 904-12 |year= 2000 |pmid= 10783144 |doi= }}
*{{cite journal | vauthors = Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H | title = The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling | journal = Blood | volume = 97 | issue = 9 | pages = 2815–22 | year = 2001 | pmid = 11313276 | doi = 10.1182/blood.V97.9.2815 }}
*{{cite journal | author=Li S, Ting NS, Zheng L, ''et al.'' |title=Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. |journal=Nature |volume=406 |issue= 6792 |pages= 210-5 |year= 2000 |pmid= 10910365 |doi= 10.1038/35018134 }}
*{{cite journal | vauthors = Melhuish TA, Gallo CM, Wotton D | title = TGIF2 interacts with histone deacetylase 1 and represses transcription | journal = J. Biol. Chem. | volume = 276 | issue = 34 | pages = 32109–14 | year = 2001 | pmid = 11427533 | doi = 10.1074/jbc.M103377200 }}
*{{cite journal | author=Zheng L, Pan H, Li S, ''et al.'' |title=Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. |journal=Mol. Cell |volume=6 |issue= 4 |pages= 757-68 |year= 2000 |pmid= 11090615 |doi= }}
*{{cite journal | vauthors = Wu-Baer F, Baer R | title = Effect of DNA damage on a BRCA1 complex | journal = Nature | volume = 414 | issue = 6859 | pages = 36 | year = 2001 | pmid = 11689934 | doi = 10.1038/35102118 }}
*{{cite journal | author=Izutsu K, Kurokawa M, Imai Y, ''et al.'' |title=The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. |journal=Blood |volume=97 |issue= 9 |pages= 2815-22 |year= 2001 |pmid= 11313276 |doi= }}
*{{cite journal | vauthors = Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE | title = The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 7849–56 | year = 2002 | pmid = 11751867 | doi = 10.1074/jbc.M110603200 }}
*{{cite journal | author=Melhuish TA, Gallo CM, Wotton D |title=TGIF2 interacts with histone deacetylase 1 and represses transcription. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32109-14 |year= 2001 |pmid= 11427533 |doi= 10.1074/jbc.M103377200 }}
*{{cite journal | vauthors = Koipally J, Georgopoulos K | title = Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression | journal = J. Biol. Chem. | volume = 277 | issue = 26 | pages = 23143–9 | year = 2002 | pmid = 11959865 | doi = 10.1074/jbc.M202079200 }}
*{{cite journal | author=Wu-Baer F, Baer R |title=Effect of DNA damage on a BRCA1 complex. |journal=Nature |volume=414 |issue= 6859 |pages= 36 |year= 2001 |pmid= 11689934 |doi= 10.1038/35102118 }}
{{Refend}}
*{{cite journal  | author=Sum EY, Peng B, Yu X, ''et al.'' |title=The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7849-56 |year= 2002 |pmid= 11751867 |doi= 10.1074/jbc.M110603200 }}
*{{cite journal | author=Koipally J, Georgopoulos K |title=Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23143-9 |year= 2002 |pmid= 11959865 |doi= 10.1074/jbc.M202079200 }}
}}
{{refend}}
 
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:03, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.[1][2][3]

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.[3]

Interactions

RBBP8 has been shown to interact with:

References

  1. ↑ 1.0 1.1 1.2 1.3 Fusco C, Reymond A, Zervos AS (October 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics. 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.
  2. ↑ Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP (November 2007). "Human CtIP promotes DNA end resection". Nature. 450 (7169): 509–14. doi:10.1038/nature06337. PMC 2409435. PMID 17965729.
  3. ↑ 3.0 3.1 "Entrez Gene: RBBP8 retinoblastoma binding protein 8".
  4. ↑ 4.0 4.1 Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH (July 2000). "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response". Nature. 406 (6792): 210–5. doi:10.1038/35018134. PMID 10910365.
  5. ↑ Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
  6. ↑ 6.0 6.1 Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH (April 1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage". J. Biol. Chem. 274 (16): 11334–8. doi:10.1074/jbc.274.16.11334. PMID 10196224.
  7. ↑ Rodriguez M, Yu X, Chen J, Songyang Z (Dec 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
  8. ↑ Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH, Bartel PL (November 1998). "Characterization of a carboxy-terminal BRCA1 interacting protein". Oncogene. 17 (18): 2279–85. doi:10.1038/sj.onc.1202150. PMID 9811458.
  9. ↑ Wu-Baer F, Baer R (November 2001). "Effect of DNA damage on a BRCA1 complex". Nature. 414 (6859): 36. doi:10.1038/35102118. PMID 11689934.
  10. ↑ Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R (September 1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression". J. Biol. Chem. 273 (39): 25388–92. doi:10.1074/jbc.273.39.25388. PMID 9738006.
  11. ↑ Yu X, Baer R (June 2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor". J. Biol. Chem. 275 (24): 18541–9. doi:10.1074/jbc.M909494199. PMID 10764811.
  12. ↑ Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G (April 1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif". J. Biol. Chem. 273 (15): 8549–52. doi:10.1074/jbc.273.15.8549. PMID 9535825.
  13. ↑ Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE (March 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867.
  14. ↑ Sutherland KD, Visvader JE, Choong DY, Sum EY, Lindeman GJ, Campbell IG (October 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi:10.1002/ijc.11343. PMID 12925972.
  15. ↑ Dick FA, Sailhamer E, Dyson NJ (May 2000). "Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins". Mol. Cell. Biol. 20 (10): 3715–27. doi:10.1128/mcb.20.10.3715-3727.2000. PMC 85672. PMID 10779361.
  16. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  17. ↑ Meloni AR, Smith EJ, Nevins JR (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9574–9. doi:10.1073/pnas.96.17.9574. PMC 22250. PMID 10449734.
  18. ↑ Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H (Dec 2003). "SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway". Oncogene. 22 (55): 8845–51. doi:10.1038/sj.onc.1206994. PMID 14654780.

Further reading

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