Oligodendroglioma history and symptoms: Difference between revisions

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==Overview==
==Overview==
When evaluating a patient for oligodendroglioma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough past medical history review. Other specific areas of focus when obtaining the history include review of common risk factors such as [[family history]] of [[brain tumors]]. Symptoms associated with oligodendroglioma include [[seizure]], [[headache]], [[nausea]], [[vomiting]], [[vertigo]], [[visual loss]], [[diplopia]], [[strabismus]], [[hemiparesis|muscle weakness]], [[numbness]], speech difficulties, mood disturbances, and personality changes.
When evaluating a [[patient]] for [[oligodendroglioma]], a [[Detailed balance|detailed]] [[History and Physical examination|history]] of the [[presenting symptom]] (onset, duration, and progression), other [[Association (statistics)|associated]] [[symptoms]], a thorough past [[medical history]] [[review]], and [[review]] of common [[risk factors]] such as [[family history]] of [[brain tumors]]. [[Oligodendroglioma]] is a [[slow]]-[[Growth|growing]], [[Infiltration (medical)|infiltrative]] [[tumor]] that may be [[Clinical|clinically]] silent for many [[Year|years]]. With [[tumor]] progression, [[symptoms]] may vary depending upon the [[Location parameter|location]], [[Size consistency|size]], and [[rate]] of [[tumor]] [[growth]]. [[Oligodendroglioma]] mainly involves the [[frontal lobe]]. [[Symptoms]] [[Association (statistics)|associated]] with [[oligodendroglioma]] include [[seizure]], [[headache]], [[nausea]], [[vomiting]], [[vertigo]], [[visual loss]], [[diplopia]], [[strabismus]], [[Hemiparesis|muscle weakness]], [[numbness]], [[speech difficulties]], [[mood disturbances]], [[personality changes]], [[memory]] [[Problem Solved|problems]], low [[energy]], [[fatigue]], [[Urgency|urge]] to [[sleep]], [[Loss function|loss]] of [[Interest (emotion)|interest]] in [[Activities of daily living|daily activities]], [[abulia]], [[Lack (manque)|lack]] of spontaneity, [[loss of consciousness]] with [[syncope]] (few [[tonic-clonic]] [[Jerking|jerks]]), and classic [[Triad (anatomy)|triad]] of [[headache]], [[nausea]], and [[papilledema]] due to [[raised intracranial pressure]].
 
==History==
==History==
*While evaluating a patient for oligodendroglioma, a detailed history of the following should be taken:<ref name="pmid21149253">{{cite journal| author=McCarthy BJ, Rankin KM, Aldape K, Bondy ML, Brännström T, Broholm H et al.| title=Risk factors for oligodendroglial tumors: a pooled international study. | journal=Neuro Oncol | year= 2011 | volume= 13 | issue= 2 | pages= 242-50 | pmid=21149253 | doi=10.1093/neuonc/noq173 | pmc=PMC3064625 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21149253  }} </ref>
*While evaluating a [[patient]] for [[oligodendroglioma]], a [[Detailed balance|detailed]] [[History and Physical examination|history]] of the following should be taken:<ref name="pmid21149253">{{cite journal| author=McCarthy BJ, Rankin KM, Aldape K, Bondy ML, Brännström T, Broholm H et al.| title=Risk factors for oligodendroglial tumors: a pooled international study. | journal=Neuro Oncol | year= 2011 | volume= 13 | issue= 2 | pages= 242-50 | pmid=21149253 | doi=10.1093/neuonc/noq173 | pmc=PMC3064625 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21149253  }} </ref>
**Presenting symptom:
**[[Presenting symptom]]:
***Onset
***Onset
***Duration
***Duration
***Progression
***Progression
**Other associated symptoms
**Other [[Association (statistics)|associated]] [[symptoms]]
**A thorough past medical history review
**A thorough past [[medical history]] [[review]]
**Review of common risk factors such as:
**[[Review]] of common [[risk factors]] such as:
***[[Family history]] of [[brain tumors]]
***[[Family history]] of [[brain tumors]]


==Symptoms==
==Symptoms==
* Oligodendroglioma is a slow-growing, infiltrative tumor that may be clinically silent for many years
* [[Oligodendroglioma]] is a slow-growing, [[Infiltration (medical)|infiltrative]] [[tumor]] that may be [[Clinical|clinically]] silent for many [[Year|years]]
* Asymptomatic patients are diagnosed based on incidental findings at the time of brain imaging performed for another reason (eg, trauma, migraine headaches)
* [[Asymptomatic]] [[patients]] are [[Diagnose|diagnosed]] based on [[Incidental finding|incidental findings]] at the [[Time series|time]] of [[brain imaging]] [[Performance status|performed]] for another [[Reasoning|reason]] (e.g: [[trauma]], [[migraine headaches]])
* Focal neurologic deficits and generalized symptoms such as headache are uncommon at the time of diagnosis
* Focal [[Neurological|neurologic]] deficits and generalized [[symptoms]] such as [[headache]] are uncommon at the [[Time series|time]] of [[diagnosis]]
* With tumor progression, symptoms may vary depending on following characteristics of tumor:
* With [[tumor]] progression, [[symptoms]] may vary [[Dependent variable|depending]] on following characteristics of [[tumor]]:
* location,
** [[Location parameter|Location]]
* size, and
** [[Size consistency|Size]]
* rate of tumor growth
** [[Rate]] of [[tumor]] [[growth]]
*  
* It mainly involves the '''[[frontal lobe]]'''
 
* Common [[symptoms]] [[Association (statistics)|associated]] with [[oligodendroglioma]] include:<ref name="pmid9684012">{{cite journal| author=Douay X, Daems-Monpeurt C, Labalette P, Blond S, Petit H| title=[Bilateral 3rd cranial nerve palsy disclosing oligodendroglioma]. | journal=Rev Neurol (Paris) | year= 1997 | volume= 153 | issue= 6-7 | pages= 430-2 | pmid=9684012 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9684012  }} </ref><ref name="pmid17553214">{{cite journal| author=Hata N, Shono T, Mizoguchi M, Matsumoto K, Guan Y, Nagata S et al.| title=Loss of heterozygosity analysis in an anaplastic oligodendroglioma arising after radiation therapy. | journal=Neurol Res | year= 2007 | volume= 29 | issue= 7 | pages= 723-6 | pmid=17553214 | doi=10.1179/016164107X208068 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17553214  }} </ref><ref name="pmid1695334">{{cite journal| author=Ogasawara H, Kiya K, Uozumi T, Sugiyama K, Kawamoto K, Ohta M| title=Multiple oligodendroglioma--case report. | journal=Neurol Med Chir (Tokyo) | year= 1990 | volume= 30 | issue= 2 | pages= 127-31 | pmid=1695334 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1695334  }} </ref><ref name="pmid2308753">{{cite journal| author=Raciti-Daurio C, Caruso J| title=Oligodendroglioma--a case presentation. | journal=Optom Vis Sci | year= 1990 | volume= 67 | issue= 1 | pages= 56-8 | pmid=2308753 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2308753  }} </ref><ref name="pmid24805856">{{cite journal| author=Rodriguez FJ, Tihan T, Lin D, McDonald W, Nigro J, Feuerstein B et al.| title=Clinicopathologic features of pediatric oligodendrogliomas: a series of 50 patients. | journal=Am J Surg Pathol | year= 2014 | volume= 38 | issue= 8 | pages= 1058-70 | pmid=24805856 | doi=10.1097/PAS.0000000000000221 | pmc=4322928 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24805856  }} </ref>
* Symptoms associated with oligodendroglioma include:<ref name="pmid9684012">{{cite journal| author=Douay X, Daems-Monpeurt C, Labalette P, Blond S, Petit H| title=[Bilateral 3rd cranial nerve palsy disclosing oligodendroglioma]. | journal=Rev Neurol (Paris) | year= 1997 | volume= 153 | issue= 6-7 | pages= 430-2 | pmid=9684012 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9684012  }} </ref><ref name="pmid17553214">{{cite journal| author=Hata N, Shono T, Mizoguchi M, Matsumoto K, Guan Y, Nagata S et al.| title=Loss of heterozygosity analysis in an anaplastic oligodendroglioma arising after radiation therapy. | journal=Neurol Res | year= 2007 | volume= 29 | issue= 7 | pages= 723-6 | pmid=17553214 | doi=10.1179/016164107X208068 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17553214  }} </ref><ref name="pmid1695334">{{cite journal| author=Ogasawara H, Kiya K, Uozumi T, Sugiyama K, Kawamoto K, Ohta M| title=Multiple oligodendroglioma--case report. | journal=Neurol Med Chir (Tokyo) | year= 1990 | volume= 30 | issue= 2 | pages= 127-31 | pmid=1695334 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1695334  }} </ref><ref name="pmid2308753">{{cite journal| author=Raciti-Daurio C, Caruso J| title=Oligodendroglioma--a case presentation. | journal=Optom Vis Sci | year= 1990 | volume= 67 | issue= 1 | pages= 56-8 | pmid=2308753 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2308753  }} </ref>
**[[Seizure]] (usually the first and most common [[Presentation (Obstetrics)|presentation]] in 50-80% of the cases)<ref name="pmid17172614">{{cite journal| author=Cavaliere R, Farace E, Schiff D| title=Clinical implications of status epilepticus in patients with neoplasms. | journal=Arch Neurol | year= 2006 | volume= 63 | issue= 12 | pages= 1746-9 | pmid=17172614 | doi=10.1001/archneur.63.12.1746 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17172614  }} </ref>
 
**[[Seizure]] (most common presentation)
**[[Headache]]
**[[Headache]]
**[[Nausea]]
**[[Nausea]]
**[[Vomiting]]
**[[Vomiting]]
**[[Vertigo]]
**[[Vertigo]]
**[[Dysarthria|Changes in speech]]
**'''Focal [[neurological]] deficits''' depending upon [[tumor]] [[Location parameter|location]] ([[symptoms]] usually [[Causes|caused]] by [[local]] [[Tissue (biology)|tissue]] [[Disruption (of schema)|disruption]], [[Mass effect (medicine)|mass effect]] on nearby [[Structure factor|structures]], or [[vasogenic edema]]) include:
**[[mood disorders|Changes in mood]]
***[[hemiparesis|Muscle weakness]]
**[[personality pathology|Changes in personality]]
***[[Numbness]]/[[sensory loss]]
**[[Visual loss]]
***[[Dysarthria|Changes in speech]]/[[aphasia]]
**[[Diplopia]]
***[[Visual loss]]/[[visual]] [[Spatial analysis|spatial]] [[dysfunction]]
**[[Strabismus]]
***[[Diplopia]]
**[[hemiparesis|Muscle weakness]]
***[[Strabismus]]
**[[Numbness]]
**'''[[Cognitive]] [[dysfunction]]''' includes:
***[[Memory]] [[Problem Solved|problems]]
***[[mood disorders|Changes in mood]]
***[[personality pathology|Changes in personality]]
***Low [[energy]]
***[[Fatigue]]
***[[Urgency|Urge]] to [[sleep]]
***[[Loss function|Loss]] of [[Interest (emotion)|interest]] in [[Activities of daily living|daily activities]]
***[[Abulia]] (showing [[abnormal]] inability to act or [[Decision making|make decisions]])
***[[Lack (manque)|Lack]] of spontaneity
**'''[[Increased intracranial pressure]]''' (either due to a [[Large-print|large]] [[mass]] or any [[restriction]] in [[cerebrospinal fluid]] outflow [[Causes|causing]] [[hydrocephalus]]) [[Association (statistics)|associated]] with following [[symptoms]]:
***Classic [[Triad (anatomy)|triad]] that includes:
****[[Headache]]
****[[Nausea]]
****[[Papilledema]]
***[[Loss of consciousness]] with [[syncope]] (maybe [[Association (statistics)|associated]] with a few [[tonic-clonic]] [[Jerking|jerks]])
{| class="wikitable"
|+Oligodendrogliomas symptoms according to tumor site
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Tumor site of involvement}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Clinical features}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''[[Frontal lobe]]'''
|
* [[Weakness]] of one [[Side chain|side]] of the [[Human body|body]]
* [[Personality changes]]
* [[Behavior change|Behavior changes]]
* Difficulty with [[short-term memory]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |'''[[Temporal lobe]]'''
|
* Usually “[[Silent News|silent]]”
* May [[Causes|cause]] few [[symptoms]] such as:
** [[Seizures]]
** [[Language]] [[Problem Solved|problems]]
|}


==References==
==References==

Latest revision as of 22:26, 18 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]

Overview

When evaluating a patient for oligodendroglioma, a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, a thorough past medical history review, and review of common risk factors such as family history of brain tumors. Oligodendroglioma is a slow-growing, infiltrative tumor that may be clinically silent for many years. With tumor progression, symptoms may vary depending upon the location, size, and rate of tumor growth. Oligodendroglioma mainly involves the frontal lobe. Symptoms associated with oligodendroglioma include seizure, headache, nausea, vomiting, vertigo, visual loss, diplopia, strabismus, muscle weakness, numbness, speech difficulties, mood disturbances, personality changes, memory problems, low energy, fatigue, urge to sleep, loss of interest in daily activities, abulia, lack of spontaneity, loss of consciousness with syncope (few tonic-clonic jerks), and classic triad of headache, nausea, and papilledema due to raised intracranial pressure.

History

Symptoms

Oligodendrogliomas symptoms according to tumor site
Tumor site of involvement Clinical features
Frontal lobe
Temporal lobe

References

  1. ↑ McCarthy BJ, Rankin KM, Aldape K, Bondy ML, Brännström T, Broholm H; et al. (2011). "Risk factors for oligodendroglial tumors: a pooled international study". Neuro Oncol. 13 (2): 242–50. doi:10.1093/neuonc/noq173. PMC 3064625. PMID 21149253.
  2. ↑ Douay X, Daems-Monpeurt C, Labalette P, Blond S, Petit H (1997). "[Bilateral 3rd cranial nerve palsy disclosing oligodendroglioma]". Rev Neurol (Paris). 153 (6–7): 430–2. PMID 9684012.
  3. ↑ Hata N, Shono T, Mizoguchi M, Matsumoto K, Guan Y, Nagata S; et al. (2007). "Loss of heterozygosity analysis in an anaplastic oligodendroglioma arising after radiation therapy". Neurol Res. 29 (7): 723–6. doi:10.1179/016164107X208068. PMID 17553214.
  4. ↑ Ogasawara H, Kiya K, Uozumi T, Sugiyama K, Kawamoto K, Ohta M (1990). "Multiple oligodendroglioma--case report". Neurol Med Chir (Tokyo). 30 (2): 127–31. PMID 1695334.
  5. ↑ Raciti-Daurio C, Caruso J (1990). "Oligodendroglioma--a case presentation". Optom Vis Sci. 67 (1): 56–8. PMID 2308753.
  6. ↑ Rodriguez FJ, Tihan T, Lin D, McDonald W, Nigro J, Feuerstein B; et al. (2014). "Clinicopathologic features of pediatric oligodendrogliomas: a series of 50 patients". Am J Surg Pathol. 38 (8): 1058–70. doi:10.1097/PAS.0000000000000221. PMC 4322928. PMID 24805856.
  7. ↑ Cavaliere R, Farace E, Schiff D (2006). "Clinical implications of status epilepticus in patients with neoplasms". Arch Neurol. 63 (12): 1746–9. doi:10.1001/archneur.63.12.1746. PMID 17172614.


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