Nephrotic syndrome classification: Difference between revisions
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| bgcolor="#d9ff54"|'''Cause''' || bgcolor="#d9ff54"|'''Characteristic Features''' | | bgcolor="#d9ff54"|'''Cause''' || bgcolor="#d9ff54"|'''Characteristic Features''' | ||
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| bgcolor="#ececec"|'''Diabetes Mellitus''' || | | bgcolor="#ececec"|'''[[Diabetes Mellitus]]''' || | ||
*[[Glucosuria]] | *[[Glucosuria]] | ||
*[[Hyperglycemia]] | *[[Hyperglycemia]] | ||
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*[[Polydipsia]] | *[[Polydipsia]] | ||
|- | |- | ||
| bgcolor="#ececec"|'''Systemic Lupus Erythematosus (SLE)''' || | | bgcolor="#ececec"|'''[[Systemic Lupus Erythematosus]] (SLE)''' || | ||
*[[Anemia]] | *[[Anemia]] | ||
*[[Arthralgia]] | *[[Arthralgia]] | ||
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*Positive [[ANA]] and [[anti-dsDNA]] antibodies | *Positive [[ANA]] and [[anti-dsDNA]] antibodies | ||
|- | |- | ||
| bgcolor="#ececec"|'''Viral Hepatitis (HBV and HCV)''' || | | bgcolor="#ececec"|'''[[Viral Hepatitis]] ([[HBV]] and [[HCV]])''' || | ||
*Elevated [[liver function test]]s | *Elevated [[liver function test]]s | ||
*History of transfusions | *History of transfusions | ||
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*Positive HBsAg or [[HCV]] RNA | *Positive HBsAg or [[HCV]] RNA | ||
|- | |- | ||
| bgcolor="#ececec"|''' | | bgcolor="#ececec"|'''[[NSAID]]s''' || | ||
*Associated with minimal change disease (MCD) | *Associated with minimal change disease (MCD) | ||
|- | |- | ||
|bgcolor="#ececec"|'''Amyloidosis''' || | |bgcolor="#ececec"|'''[[Amyloidosis]]''' || | ||
*[[Cardiomyopathy]] | *[[Cardiomyopathy]] | ||
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*[[Peripheral neuropathy]] | *[[Peripheral neuropathy]] | ||
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| bgcolor="#ececec"|'''Multiple Myeloma''' || | | bgcolor="#ececec"|'''[[Multiple Myeloma]]''' || | ||
*Abrnomal urine protein electrophoresis (UPEP) and serum protein electrophoresis (SPEP) | *Abrnomal [[urine protein electrophoresis]] (UPEP) and [[serum protein electrophoresis]] (SPEP) | ||
*[[Back pain]] | *[[Back pain]] | ||
*[[Renal failure]] | *[[Renal failure]] | ||
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*Positive serum beta-2-microglobulin | *Positive serum beta-2-microglobulin | ||
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| bgcolor="#ececec"|'''HIV''' || | | bgcolor="#ececec"|'''[[HIV]]''' || | ||
*Reduced [[CD4]] cell counts | *Reduced [[CD4]] cell counts | ||
*High-risk sexual encounters | *High-risk sexual encounters | ||
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*Renal pathology similar to [[focal segmental glomerulosclerosis]] (FSGS) | *Renal pathology similar to [[focal segmental glomerulosclerosis]] (FSGS) | ||
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| bgcolor="#ececec"|'''Preeclampsia''' || | | bgcolor="#ececec"|'''[[Preeclampsia]]''' || | ||
*[[High blood pressure]], [[edema]], and [[proteinuria]] during pregnancy | *[[High blood pressure]], [[edema]], and [[proteinuria]] during pregnancy | ||
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Revision as of 00:47, 5 April 2015
Nephrotic Syndrome Microchapters |
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Nephrotic syndrome classification On the Web |
American Roentgen Ray Society Images of Nephrotic syndrome classification |
Risk calculators and risk factors for Nephrotic syndrome classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, Serge Korjian
Overview
Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology. Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary glomerular disease. Secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as infections, malignancies, systemic conditions, and medications.
Classification
Etiologic Classification
Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.
Nephrotic syndrome | |||||||||||||||||||
Primary | Secondary | ||||||||||||||||||
Primary (Idiopathic) Nephrotic Syndrome
Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary glomerular disease. It is a common diagnosis in children. Etiologies of idiopathic nephrotic syndrome include:[1]:
- Minimal change disease
- Focal segmental glomerulosclerosis (FSGS)
- Membranous nephropathy
- Membranoproliferative glomerulonephritis
- IgM nephropathy
- C1q nephropathy
Secondary Nephrotic Syndrome
Secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as infections, malignancies, systemic conditions, and medications. The most common cause of secondary nephrotic syndrome is diabetes mellitus.
Cause | Characteristic Features |
Diabetes Mellitus | |
Systemic Lupus Erythematosus (SLE) |
|
Viral Hepatitis (HBV and HCV) |
|
NSAIDs |
|
Amyloidosis | |
Multiple Myeloma |
|
HIV |
|
Preeclampsia |
|
References
- ↑ 1.0 1.1 Kodner C (2009). "Nephrotic syndrome in adults: diagnosis and management". Am Fam Physician. 80 (10): 1129–34. PMID 19904897.
- ↑ Hull RP, Goldsmith DJ (2008). "Nephrotic syndrome in adults". BMJ. 336 (7654): 1185–9. doi:10.1136/bmj.39576.709711.80. PMC 2394708. PMID 18497417.