Nephrotic syndrome diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mehrian Jafarizade, M.D [2]
Overview
Proteinuria could be measured by 24-hour urine collection. Urine protein above 3.5 g/day is considered as nephrotic range proteinuria. Diagnostic study of choice for nephrotic syndrome is kidney biopsy that reveals the exact type of disease and the its progression.
Diagnostic Study of Choice
Study of choice
- Proteinuria could be measured by 24-hour urine collection. Urine protein above 3.5 g/day is considered as nephrotic range proteinuria.[1][2]
- Kidney biopsy is the gold standard test for the diagnosis of the underlying cause of nephrotic syndrome.[3]
Relative contrandications of the kidney biopsy:
- Single kidney
- Anatomic kidney abnormalities
- Small size kidneys (less than 9 cm), indicative of end stage renal disease
- Renal tumor
- Multiple, bilateral renal cysts
- Active infection in the kidney or on the skin over the biopsy side
- Uncorrectable bleeding diathesis
- Severe uncontrolled hypertension
- Hydronephrosis
- Uncooperative patient
References
- ↑ Liebeskind, David S. (2014). "Nephrotic syndrome". 119: 405–415. doi:10.1016/B978-0-7020-4086-3.00026-6. ISSN 0072-9752.
- ↑ Sinha, Aditi; Bagga, Arvind (2012). "Nephrotic Syndrome". The Indian Journal of Pediatrics. 79 (8): 1045–1055. doi:10.1007/s12098-012-0776-y. ISSN 0019-5456.
- ↑ "Clinical competence in percutaneous renal biopsy. Health and Public Policy Committee. American College of Physicians". Ann. Intern. Med. 108 (2): 301–3. February 1988. PMID 3341661.