Myelodysplastic syndrome medical therapy: Difference between revisions

Jump to navigation Jump to search
No edit summary
(Mahshid)
 
(2 intermediate revisions by one other user not shown)
Line 3: Line 3:
{{CMG}};{{AE}}{{NM}}
{{CMG}};{{AE}}{{NM}}
==Overview==
==Overview==
Chemotherapy is recommended among all patients who develop myelodysplastic syndrome.<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
[[Chemotherapy]] is recommended among all patients who develop myelodysplastic syndrome.<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
==Medical Therapy==
==Medical Therapy==
*Treatment is based on the type of myelodysplastic syndrome and the person's age and general health. The goal of treatment for myelodysplastic syndrome is to:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*Treatment is based on the type of myelodysplastic syndrome and the person's age and general health. The goal of treatment for myelodysplastic syndrome is to:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
Line 10: Line 10:
**Improve quality of life
**Improve quality of life
===Chemotherapy===
===Chemotherapy===
* The most common chemotherapy drug used to treat MDS is cytarabine. Cytarabine may be combined with other pharmacological agents such as:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*The most common chemotherapy drug used to treat myelodysplastic syndrome is cytarabine. Cytarabine may be combined with other pharmacological agents such as:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
**Idarubicin  
**[[Idarubicin]]
**Topotecan  
**[[Topotecan]]
**Fludarabine
**[[Fludarabine]]
* Other chemotherapeutic agents that may be used to treat myelodysplastic syndrome include:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
* Other chemotherapeutic agents that may be used to treat myelodysplastic syndrome include:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
**Daunorubucin  
**[[Daunorubucin]]
**Mitoxantrone  
**[[Mitoxantrone]]
===Supportive Therapy===
===Supportive Therapy===
*Supportive therapy is given to relieve symptoms and lessen the problems caused by abnormal blood cell counts or treatment for myelodysplastic syndrome.<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*Supportive therapy is given to relieve symptoms and lessen the problems caused by abnormal blood cell counts or treatment for myelodysplastic syndrome.<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
Line 24: Line 24:
*Patients with bleeding problems due to low platelet counts may be given platelet transfusions.
*Patients with bleeding problems due to low platelet counts may be given platelet transfusions.
====Growth Factors====
====Growth Factors====
*Epoetin (erythropoietin)
*[[Epoetin]] (erythropoietin)
:*Helps improve production of red blood cells
:*Helps improve production of red blood cells
*Filgrastim  
*[[Filgrastim]]
:*Also called granulocyte colony-stimulating factor (G-CSF)
:*Also called granulocyte colony-stimulating factor (G-CSF)
:*Helps improve production of white blood cells
:*Helps improve production of white blood cells
*Pegfilgrastim  
*[[Pegfilgrastim]]
:*A long-acting G-CSF
:*A long-acting G-CSF
====Supportive Therapy====
====Supportive Therapy====
*Other drugs that may be used to treat symptoms or side effects of therapy include:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*Other drugs that may be used to treat symptoms or side effects of therapy include:<ref name=cancerca>Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015</ref>
*Deferoxamine  
*[[Deferoxamine]]
:*treats excess iron in the blood
:*treats excess iron in the blood
:*sometimes given with Vitamin C.
:*sometimes given with Vitamin C.
*Lenalidomide  
*[[Lenalidomide]]
:*decreases the need for transfusions in people with a specific chromosome change
:*decreases the need for transfusions in people with a specific chromosome change
*Antithymocyte globulin  
*[[Antithymocyte globulin]]
:*decreases the need for transfusions in certain types of myelodysplastic syndrome
:*decreases the need for transfusions in certain types of myelodysplastic syndrome
*Antibiotics
*Antibiotics
:*help to prevent or treat infections
:*help to prevent or treat infections
*Hypomethylating agents, such as 5-azacytidine or decitabine  
*Hypomethylating agents, such as [[5-azacytidine]] or [[decitabine]]
:*stop cancer cells from producing DNA or RNA so the cells die
:*stop cancer cells from producing DNA or RNA so the cells die
==References==
==References==
Line 53: Line 53:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Neurology]]
[[Category:Neurosurgery]]

Latest revision as of 02:49, 27 November 2017

Myelodysplastic syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Myelodysplastic syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Myelodysplastic syndrome medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Myelodysplastic syndrome medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Myelodysplastic syndrome medical therapy

CDC on Myelodysplastic syndrome medical therapy

Myelodysplastic syndrome medical therapy in the news

Blogs on Myelodysplastic syndrome medical therapy

Directions to Hospitals Treating Myelodysplastic syndrome

Risk calculators and risk factors for Myelodysplastic syndrome medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Chemotherapy is recommended among all patients who develop myelodysplastic syndrome.[1]

Medical Therapy

  • Treatment is based on the type of myelodysplastic syndrome and the person's age and general health. The goal of treatment for myelodysplastic syndrome is to:[1]
    • Relieve symptoms
    • Slow or prevent progression of the disease
    • Improve quality of life

Chemotherapy

  • The most common chemotherapy drug used to treat myelodysplastic syndrome is cytarabine. Cytarabine may be combined with other pharmacological agents such as:[1]
  • Other chemotherapeutic agents that may be used to treat myelodysplastic syndrome include:[1]

Supportive Therapy

  • Supportive therapy is given to relieve symptoms and lessen the problems caused by abnormal blood cell counts or treatment for myelodysplastic syndrome.[1]

Transfusions

  • Patients with anemia may receive blood transfusions to correct the red blood cell counts.
  • Frequent blood transfusions can be complicated by a buildup of extra iron in the body, which is treated with drug therapy.
  • Patients with bleeding problems due to low platelet counts may be given platelet transfusions.

Growth Factors

  • Helps improve production of red blood cells
  • Also called granulocyte colony-stimulating factor (G-CSF)
  • Helps improve production of white blood cells
  • A long-acting G-CSF

Supportive Therapy

  • Other drugs that may be used to treat symptoms or side effects of therapy include:[1]
  • Deferoxamine
  • treats excess iron in the blood
  • sometimes given with Vitamin C.
  • decreases the need for transfusions in people with a specific chromosome change
  • decreases the need for transfusions in certain types of myelodysplastic syndrome
  • Antibiotics
  • help to prevent or treat infections
  • stop cancer cells from producing DNA or RNA so the cells die

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Treatment of myelodysplastic syndrome. National Cancer Institute (2015). http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/myelodysplastic-syndromes/?region=on. Accessed on December 15, 2015


Template:WikiDoc Sources