Cholangiocarcinoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Historical Perspective
Discovery
- In 1973, 64 years old man was first case of primary intrahepatic cholangiocarcinoma with right upper quadrant pain, jaundice, and weight loss.[1]
- Following mutations were first implicated in the pathogenesis of cholangiocarcinoma:
- Dimensional-differential gel electrophoresis couple with liquid chromatography tandem mass spectrometry (2D-DIGE/LC-MS-MS)
- Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS)
- Surface enhanced laser desorption/ionization (SELDI)-TOF-MS
- Capillary electrophoresis (CE)-MS
Landmark Events in the Development of Treatment Strategies
- In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
Famous Cases
- The following are a few famous cases of disease name:
References
- ↑ Lubana SS, Singh N, Seligman B, Tuli SS, Heimann DM (2015). "First Reported Case of Primary Intrahepatic Cholangiocarcinoma with Pure Squamous Cell Histology: A Case Report". Am J Case Rep. 16: 438–44. doi:10.12659/AJCR.894609. PMC 4501643. PMID 26158884.