Central pontine myelinolysis natural history, complications and prognosis: Difference between revisions
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===Prognosis=== | ===Prognosis=== | ||
*Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with central pontine myelinolysis is approximately [--]%. | *Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with central pontine myelinolysis is approximately [--]%. | ||
*Depending on the | *Depending on the time of the diagnosis, the prognosis may vary and the disease may be potentially reversible when therapeutic interventions are initiated rapidly. | ||
*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with central pontine myelinolysis. | *The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with central pontine myelinolysis. | ||
*[Subtype of disease/malignancy] is associated with the most favorable prognosis. | *[Subtype of disease/malignancy] is associated with the most favorable prognosis. |
Revision as of 15:28, 25 September 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- The symptoms of central pontine myelinolysis typically develop immediately after injury to the neurons of the brain stem.
Complications
- Patients, with Central Pontine Myelinolysis, may develop permanent neurological damages.
- Common complications of central pontine myelinolysis include:[1][2][3][4][5][6]
- Locked-in syndrome
- Quadriparesis
- Ataxia
- Acute Psychosis
- Pseudobulbar palsy
- Parkinson's disease symptoms
- Dystonia
- Pneumonia
- Coma
- Death
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with central pontine myelinolysis is approximately [--]%.
- Depending on the time of the diagnosis, the prognosis may vary and the disease may be potentially reversible when therapeutic interventions are initiated rapidly.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with central pontine myelinolysis.
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of the tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ Sohn MK, Nam JH (2014). "Locked-in Syndrome due to Central Pontine Myelinolysis: Case Report". Ann Rehabil Med. 38 (5): 702–6. doi:10.5535/arm.2014.38.5.702. PMC 4221401. PMID 25379502.
- ↑ Gopal M, Parasram M, Patel H, Ilorah C, Nersesyan H (2017). "Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis". Case Rep Neurol Med. 2017: 1471096. doi:10.1155/2017/1471096. PMC 5368399. PMID 28392953.
- ↑ Pfister HW, Einhäupl KM, Brandt T (1985). "Mild central pontine myelinolysis: a frequently undetected syndrome". Eur Arch Psychiatry Neurol Sci. 235 (3): 134–9. PMID 4092709.
- ↑ Dolciotti C, Nuti A, Cipriani G, Borelli P, Baldacci F, Logi C; et al. (2010). "Cerebellar ataxia with complete clinical recovery and resolution of MRI lesions related to central pontine myelinolysis: case report and literature review". Case Rep Neurol. 2 (3): 157–62. doi:10.1159/000323429. PMC 3098816. PMID 21607027.
- ↑ Seiser A, Schwarz S, Aichinger-Steiner MM, Funk G, Schnider P, Brainin M (1998). "Parkinsonism and dystonia in central pontine and extrapontine myelinolysis". J Neurol Neurosurg Psychiatry. 65 (1): 119–21. doi:10.1136/jnnp.65.1.119. PMC 2170170. PMID 9667573.
- ↑ Grech R, Galvin L, Brennan P, Thornton J (2013). "Central pontine myelinolysis". BMJ Case Rep. 2013. doi:10.1136/bcr-2013-008920. PMC 3645781. PMID 23608854.