Brain tumor staging: Difference between revisions
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After a brain tumor has been diagnosed, additional tests will be done to learn more about the tumor. If the tumor is a glial brain tumor, the pathologist will assign a “grade” using a number from I to IV (one to four). The grade indicates how different the tumor cells are from healthy cells, with a higher grade tumor having cells that are the least like healthy cells. The characteristics of the tumor, as seen under the microscope, help determine how cancerous a tumor is. Generally, the lower the grade, the better the prognosis (chance of recovery or long-term control of the tumor). | After a brain tumor has been diagnosed, additional tests will be done to learn more about the tumor. If the tumor is a glial brain tumor, the pathologist will assign a “grade” using a number from I to IV (one to four). The grade indicates how different the tumor cells are from healthy cells, with a higher grade tumor having cells that are the least like healthy cells. The characteristics of the tumor, as seen under the microscope, help determine how cancerous a tumor is. Generally, the lower the grade, the better the prognosis (chance of recovery or long-term control of the tumor). | ||
==WHO Histologic Grading for CNS Tumors== | ==WHO Histologic Grading for CNS Tumors== | ||
===Grade I=== | |||
* Lesions with low proliferative potential, a frequently discrete nature, and the possibility of cure following surgical resection alone | * Lesions with low proliferative potential, a frequently discrete nature, and the possibility of cure following surgical resection alone | ||
* Juvenile pilocytic astrocytoma, subependymal giant cell astrocytoma | * Juvenile pilocytic astrocytoma, subependymal giant cell astrocytoma | ||
===Grade II=== | |||
* Lesions that are generally infiltrating and low in mitotic activity but recur; some tumor types tend to progress to higher grades of malignancy | * Lesions that are generally infiltrating and low in mitotic activity but recur; some tumor types tend to progress to higher grades of malignancy | ||
* Diffuse astrocytoma, oligodendroglioma, oligoastrocytoma | * Diffuse astrocytoma, oligodendroglioma, oligoastrocytoma | ||
===Grade III=== | |||
* Lesions with histologic evidence of malignancy, generally in the form of mitotic activity, clearly expressed infiltrative capabilities, and anaplasia | * Lesions with histologic evidence of malignancy, generally in the form of mitotic activity, clearly expressed infiltrative capabilities, and anaplasia | ||
* Anaplastic astrocytoma, anaplastic oligoastrocytoma, anaplastic oligoastrocytoma | * Anaplastic astrocytoma, anaplastic oligoastrocytoma, anaplastic oligoastrocytoma | ||
===Grade IV=== | |||
* Lesions that are mitotically active, necrosis-prone, and generally associated with a rapid preoperative and postoperative evolution of disease | * Lesions that are mitotically active, necrosis-prone, and generally associated with a rapid preoperative and postoperative evolution of disease | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Primary care]] | |||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Brain]] | [[Category:Brain]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} |
Revision as of 18:20, 28 March 2013
Brain tumor Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Staging is a way of describing a tumor, such as where it is located, if or where it has spread, and whether it is affecting the functions of other organs in the body. A staging system is used for most other types of cancer. There is a formal staging system for adult brain tumors; however, the grading system described below is always used instead.
After a brain tumor has been diagnosed, additional tests will be done to learn more about the tumor. If the tumor is a glial brain tumor, the pathologist will assign a “grade” using a number from I to IV (one to four). The grade indicates how different the tumor cells are from healthy cells, with a higher grade tumor having cells that are the least like healthy cells. The characteristics of the tumor, as seen under the microscope, help determine how cancerous a tumor is. Generally, the lower the grade, the better the prognosis (chance of recovery or long-term control of the tumor).
WHO Histologic Grading for CNS Tumors
Grade I
- Lesions with low proliferative potential, a frequently discrete nature, and the possibility of cure following surgical resection alone
- Juvenile pilocytic astrocytoma, subependymal giant cell astrocytoma
Grade II
- Lesions that are generally infiltrating and low in mitotic activity but recur; some tumor types tend to progress to higher grades of malignancy
- Diffuse astrocytoma, oligodendroglioma, oligoastrocytoma
Grade III
- Lesions with histologic evidence of malignancy, generally in the form of mitotic activity, clearly expressed infiltrative capabilities, and anaplasia
- Anaplastic astrocytoma, anaplastic oligoastrocytoma, anaplastic oligoastrocytoma
Grade IV
- Lesions that are mitotically active, necrosis-prone, and generally associated with a rapid preoperative and postoperative evolution of disease
- Glioblastoma