Brain tumor staging

Jump to: navigation, search

Brain tumor Microchapters


Patient Information


Historical Perspective




Differentiating Brain Tumor from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis



History and Symptoms

Physical Examination

Laboratory Findings

X Ray



Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Brain tumor staging On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Brain tumor staging

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Brain tumor staging

CDC on Brain tumor staging

Brain tumor staging in the news

Blogs on Brain tumor staging

Directions to Hospitals Treating Brain tumor

Risk calculators and risk factors for Brain tumor staging

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]


The subtypes of brain tumors have different staging systems based on the grade, extent of spread, size and presence of distant metastases. According to WHO histologic grading for brain tumors, the grades of brain tumors are subdivided into Grades 1,2,3 and 4. The lower the grade, better the prognosis.

WHO Histologic Grading for CNS Tumors

According to WHO histologic grading for brain tumors, the grades of brain tumors are subdivided into Grades 1,2,3 and 4.[1]

Grade I

  • Lesions with low proliferative potential, a frequently discrete nature, and the possibility of cure following surgical resection alone
    • Juvenile pilocytic astrocytoma
    • Subependymal giant cell astrocytoma

Grade II

  • Lesions that are generally infiltrating and low in mitotic activity but recur; some tumor types tend to progress to higher grades of malignancy
    • Pilomyxoid astrocytoma
    • Pleomorphic xanthoastrocytoma
    • Diffuse astrocytoma
    • Fibrillary astrocytoma
    • Protoplasmic astrocytoma
    • Gemistocytic astrocytoma

Grade III

  • Lesions with histologic evidence of malignancy, generally in the form of mitotic activity, clearly expressed infiltrative capabilities, and anaplasia
    • Anaplastic astrocytoma

Grade IV

  • Lesions that are mitotically active, necrosis-prone, and generally associated with a rapid preoperative and postoperative evolution of disease
    • Glioblastoma
    • Giant cell glioblastoma
    • Gliosarcoma
    • Gliomatosis cerebri[1]


  1. 1.0 1.1 Grading of brain tumors.Dr Amir Rezaee and Dr Frank Gaillard et al. 2015.