Aplastic anemia classification: Difference between revisions

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{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]  {{N.F}}
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]  {{N.F}}
==Overview==
==Overview==
[[Aplastic anemia]] can be classified into mild, moderate, severe, and very severe depending on the severity of cellularity of [[bone marrow]] and the blood tests.
 
Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).


==Classification==
==Classification==
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!vSAA
!vSAA
|-
|-
|Reticulocytes
|[[Reticulocytes]]
|<20G/L
|<20G/L
|<20G/L
|<20G/L
|<20G/L                                       
|<20G/L                                       
|-
|-
|Platelets
|[[Platelet|Platelets]]
|<50 G / L                               
|<50 G / L                               
|<20G/L                               
|<20G/L                               
|<20G/L                                   
|<20G/L                                   
|-
|-
|Neutrophilic granulocytes
|[[Granulocytes|Neutrophilic granulocytes]]
|<1.0 G / L
|<1.0 G / L
|<0.5G/L
|<0.5G/L
Line 41: Line 42:
!
!
|-
|-
|Idiopathic
|[[Idiopathic]]
|
|
|-
|-
|Secondry                 
|Secondry                 
|Irradiation                                                                                         
|[[Irradiation]]                                                                                        
Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold  
Drugs and chemicals: cytotoxic agents, [[benzene]], chloromphenicol, [[gold]]


salts, NSAIDS
salts, [[Non-steroidal anti-inflammatory drug|NSAIDS]]


Idiosyncratic reactions
[[Idiosyncratic drug reaction|Idiosyncratic]] reactions


Viruses: Epstein Barr virus, parvovirus B19, HIV
Viruses: [[Epstein Barr virus]], [[parvovirus B19]], [[Human Immunodeficiency Virus (HIV)|HIV]]


Immune diseases
Immune diseases


Pregnancy
[[Pregnancy]]


PNH
[[PNH]] [[Paroxysmal nocturnal hemoglobinuria]]
|-
|-
|'''''Inherited aplastic anemia'''''
|'''''Inherited aplastic anemia'''''
|Fanconis anemia
|[[Fanconi anemia]]
Dyskeratosis congenital
[[Dyskeratosis congenita|Dyskeratosis congenital]]


Amegakaryocytic thrombocytopenia
[[Amegakaryocytic thrombocytopenia]]


Shwachman-Diamond syndrome
[[Shwachman-Diamond syndrome]]
|}
|}



Revision as of 20:01, 14 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.

Overview

Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).

Classification

Aplastic anemia may be classified according to blood cell counts into 3 subgroups:[1]

    • Moderately severe aplastic anemia or non severe AA (nSAA)
    • Severe aplastic anemia (SAA)
    • Very severe aplastic anemia(vSAA)
Classification of aplastic anemia (two out of three criteria must be met)
nSAA SAA vSAA
Reticulocytes <20G/L <20G/L <20G/L
Platelets <50 G / L <20G/L <20G/L
Neutrophilic granulocytes <1.0 G / L <0.5G/L 0.2G/L

This classification is of prognostic relevance and has an influence on therapeutic procedures.

classification based on the presumed etiology
Acquired aplastic anemia
Idiopathic
Secondry Irradiation

Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold

salts, NSAIDS

Idiosyncratic reactions

Viruses: Epstein Barr virus, parvovirus B19, HIV

Immune diseases

Pregnancy

PNH Paroxysmal nocturnal hemoglobinuria

Inherited aplastic anemia Fanconi anemia

Dyskeratosis congenital

Amegakaryocytic thrombocytopenia

Shwachman-Diamond syndrome

References

  1. Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.